Plakophilin-3

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PKP3
Identifiers
Aliases PKP3, plakophilin 3
External IDs MGI: 1891830 HomoloGene: 5200 GeneCards: PKP3
RNA expression pattern
PBB GE PKP3 209872 s at fs.png

PBB GE PKP3 209873 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007183
NM_001303029

NM_001162924
NM_019762

RefSeq (protein)

NP_001289958
NP_009114

NP_001156396.1
NP_062736.2
NP_001156396
NP_062736

Location (UCSC) Chr 11: 0.39 – 0.4 Mb Chr 7: 141.08 – 141.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Plakophilin-3 is a protein that in humans is encoded by the PKP3 gene.[3][4]

Function[edit]

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.[4]

Interactions[edit]

PKP3 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schmidt A, Langbein L, Prätzel S, Rode M, Rackwitz HR, Franke WW (Jun 1999). "Plakophilin 3--a novel cell-type-specific desmosomal plaque protein". Differentiation. 64 (5): 291–306. doi:10.1046/j.1432-0436.1999.6450291.x. PMID 10374265. 
  4. ^ a b "Entrez Gene: PKP3 plakophilin 3". 
  5. ^ a b c d Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (Apr 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904Freely accessible. PMID 12707304. 

Further reading[edit]