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Desmoglein 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DSG2 ; ARVC10; ARVD10; CDHF5; CMD1BB; HDGC
External IDs OMIM125671 MGI1196466 HomoloGene1464 GeneCards: DSG2 Gene
RNA expression pattern
PBB GE DSG2 217901 at tn.png
More reference expression data
Species Human Mouse
Entrez 1829 13511
Ensembl ENSG00000046604 ENSMUSG00000044393
UniProt Q14126 O55111
RefSeq (mRNA) NM_001943 NM_007883
RefSeq (protein) NP_001934 NP_031909
Location (UCSC) Chr 18:
31.5 – 31.55 Mb
Chr 18:
20.56 – 20.6 Mb
PubMed search [1] [2]

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene.[1][2]


Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein-2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.[2]


Desmoglein-2 has been shown to interact with:

See also[edit]


  1. ^ Arnemann J, Spurr NK, Magee AI, Buxton RS (July 1992). "The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18". Genomics 13 (2): 484–6. doi:10.1016/0888-7543(92)90280-6. PMID 1612610. 
  2. ^ a b "Entrez Gene: DSG2 desmoglein 2". 
  3. ^ Chitaev NA, Troyanovsky SM (1997). "Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion". J. Cell Biol. 138 (1): 193–201. doi:10.1083/jcb.138.1.193. PMC 2139935. PMID 9214392. 
  4. ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304. 
  5. ^ Bannon LJ, Cabrera BL, Stack MS, Green KJ (2001). "Isoform-specific differences in the size of desmosomal cadherin/catenin complexes". J. Invest. Dermatol. 117 (5): 1302–6. doi:10.1046/j.1523-1747.2001.01512.x. PMID 11710948. 
  6. ^ Nieset JE, Sacco-Bubulya PA, Sadler TM, Johnson KR, Wheelock MJ, Jk3rd (2000). "The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2". J. Cell. Sci. 113 (10): 1737–45. PMID 10769205. 
  7. ^ Ozawa M, Terada H, Pedraza C (1995). "The fourth armadllo repeat of plakoglobin (gamma-catenin) is required for its high affinity binding to the cytoplasmic domains of E-cadherin and desmosomal cadherin Dsg2, and the tumor suppressor APC protein". J. Biochem. 118 (5): 1077–82. doi:10.1093/jb/118.5.1077. PMID 8749329. 

Further reading[edit]

External links[edit]