Desmoglein-3

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desmoglein 3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DSG3, CDHF6, PVA, desmoglein 3
External IDs MGI: 99499 HomoloGene: 55513 GeneCards: 1830
Genetically Related Diseases
Disease Name References
Parkinson's disease
RNA expression pattern
PBB GE DSG3 205595 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001944

NM_030596

RefSeq (protein)

NP_001935.2

n/a

Location (UCSC) Chr 18: 31.45 – 31.48 Mb Chr 18: 20.51 – 20.54 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.[1][2]

Function[edit]

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.[2]

Interactions[edit]

Desmoglein 3 has been shown to interact with PKP3.[3]

See also[edit]

References[edit]

  1. ^ Arnemann J, Spurr NK, Buxton RS (Jul 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Hum Genet 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426. 
  2. ^ a b "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)". 
  3. ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304. 

Further reading[edit]