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Desmoglein 3
Symbols DSG3 ; CDHF6; PVA
External IDs OMIM169615 MGI99499 HomoloGene55513 GeneCards: DSG3 Gene
RNA expression pattern
PBB GE DSG3 205595 at tn.png
More reference expression data
Species Human Mouse
Entrez 1830 13512
Ensembl ENSG00000134757 ENSMUSG00000056632
UniProt P32926 n/a
RefSeq (mRNA) NM_001944 NM_030596
RefSeq (protein) NP_001935 NP_085099
Location (UCSC) Chr 18:
31.45 – 31.48 Mb
Chr 18:
20.51 – 20.54 Mb
PubMed search [1] [2]

Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.[1][2]


Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.[2]


Desmoglein 3 has been shown to interact with PKP3.[3]

See also[edit]


  1. ^ Arnemann J, Spurr NK, Buxton RS (Jul 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Hum Genet 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426. 
  2. ^ a b "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)". 
  3. ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304. 

Further reading[edit]