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Periplakin

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PPL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPL, periplakin
External IDsOMIM: 602871; MGI: 1194898; HomoloGene: 2026; GeneCards: PPL; OMA:PPL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002705

NM_008909

RefSeq (protein)

NP_002696

NP_032935

Location (UCSC)Chr 16: 4.88 – 4.96 MbChr 16: 4.9 – 4.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Periplakin is a protein that in humans is encoded by the PPL gene.[5][6][7]

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.[7]

Interactions

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PPL (gene) has been shown to interact with Keratin 8[8] and Envoplakin.[9][10]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118898Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039457Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics. 49 (1): 157–9. doi:10.1006/geno.1997.5206. PMID 9570964.
  6. ^ Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. doi:10.1006/geno.1997.5188. PMID 9521878.
  7. ^ a b "Entrez Gene: PPL periplakin".
  8. ^ Kazerounian S, Uitto Jouni, Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5). Denmark: 428–38. doi:10.1034/j.1600-0625.2002.110506.x. ISSN 0906-6705. PMID 12366696. S2CID 25735126.
  9. ^ Karashima T, Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell Sci. 115 (Pt 24). England: 5027–37. doi:10.1242/jcs.00191. ISSN 0021-9533. PMID 12432088. S2CID 22383123.
  10. ^ Ruhrberg C, Hajibagheri M A, Parry D A, Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. 139 (7). UNITED STATES: 1835–49. doi:10.1083/jcb.139.7.1835. ISSN 0021-9525. PMC 2132639. PMID 9412476.

Further reading

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