PPM1D

PPM1D
Identifiers
Aliases	PPM1D, PP2C-DELTA, WIP1, protein phosphatase, Mg2+/Mn2+ dependent 1D, IDDGIP, JDVS, WIP1 protein, human, PPM1D protein, human
External IDs	OMIM: 605100; MGI: 1858214; HomoloGene: 31185; GeneCards: PPM1D; OMA:PPM1D - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	60,666,280 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	85,237,892 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; amniotic fluid; ; placenta; ; ganglionic eminence; ; jejunal mucosa; ; germinal epithelium; ; Achilles tendon; ; retinal pigment epithelium; ; visceral pleura; ; sperm;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; medial ganglionic eminence; ; cerebellar vermis; ; secondary oocyte; ; hand; ; Paneth cell; ; maxillary prominence; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; catalytic activity; phosphoprotein phosphatase activity; hydrolase activity; metal ion binding; cation binding; mitogen-activated protein kinase binding; protein serine/threonine kinase activity;
Cellular component	nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	cellular response to starvation; cell cycle; response to radiation; protein dephosphorylation; G2/M transition of mitotic cell cycle; response to bacterium; peptidyl-threonine dephosphorylation; negative regulation of cell population proliferation; DNA methylation; transcription initiation from RNA polymerase II promoter; protein phosphorylation; negative regulation of gene expression, epigenetic; DNA damage response, signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	8493
	53892
	ENSG00000170836
	ENSMUSG00000020525
	O15297
	Q9QZ67
	NM_003620
	NM_016910
	NP_003611
	NP_058606
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.^[5]^[6]

Template:PBB Summary

Interactions

PPM1D has been shown to interact with CDC5L.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170836 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020525 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E (July 1997). "Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner". Proc Natl Acad Sci U S A. 94 (12): 6048–53. Bibcode:1997PNAS...94.6048F. doi:10.1073/pnas.94.12.6048. PMC 20998. PMID 9177166.
^ "Entrez Gene: PPM1D protein phosphatase 1D magnesium-dependent, delta isoform".
^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23). ENGLAND: 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading