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Aliases PPP1R3C, PPP1R5, protein phosphatase 1 regulatory subunit 3C, PTG
External IDs MGI: 1858229 HomoloGene: 3938 GeneCards: PPP1R3C
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PPP1R3C
Genomic location for PPP1R3C
Band 10q23.32 Start 91,628,442 bp[1]
End 91,633,054 bp[1]
RNA expression pattern
PBB GE PPP1R3C 204284 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 91.63 – 91.63 Mb Chr 10: 36.73 – 36.74 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Protein phosphatase 1 regulatory subunit 3C also known as PTG is an enzyme that in humans is encoded by the PPP1R3C gene.[5][6]


Protein phosphatase-1 (PP1) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits GM, GL, PTG and R6 and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8).[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119938 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067279 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Doherty MJ, Young PR, Cohen PT (Jan 1997). "Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1". FEBS Lett. 399 (3): 339–43. doi:10.1016/S0014-5793(96)01357-9. PMID 8985175. 
  6. ^ a b "Entrez Gene: PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C". 

Further reading[edit]