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PPP1R3C

From Wikipedia, the free encyclopedia
PPP1R3C
Identifiers
AliasesPPP1R3C, PPP1R5, protein phosphatase 1 regulatory subunit 3C, PTG
External IDsOMIM: 602999; MGI: 1858229; HomoloGene: 3938; GeneCards: PPP1R3C; OMA:PPP1R3C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005398

NM_016854

RefSeq (protein)

NP_005389

NP_058550

Location (UCSC)Chr 10: 91.63 – 91.63 MbChr 19: 36.71 – 36.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1 regulatory subunit 3C also known as PTG is an enzyme that in humans is encoded by the PPP1R3C gene.[5][6]

Function

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Protein phosphatase-1 (PP1) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits GM, GL, PTG and R6 and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8).[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119938Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067279Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Doherty MJ, Young PR, Cohen PT (Jan 1997). "Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1". FEBS Lett. 399 (3): 339–43. doi:10.1016/S0014-5793(96)01357-9. PMID 8985175. S2CID 31243700.
  6. ^ a b "Entrez Gene: PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C".

Further reading

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