PPP2R3A

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PPP2R3A
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases PPP2R3A, PPP2R3, PR130, PR72, protein phosphatase 2 regulatory subunit Balpha
External IDs MGI: 2442104 HomoloGene: 20595 GeneCards: PPP2R3A
RNA expression pattern
PBB GE PPP2R3A 207749 s at fs.png

PBB GE PPP2R3A 209632 at fs.png

PBB GE PPP2R3A 209633 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190447
NM_002718
NM_181897

NM_001161362
NM_172144

RefSeq (protein)

NP_001177376
NP_002709
NP_871626

n/a

Location (UCSC) Chr 3: 135.97 – 136.15 Mb Chr 9: 101.11 – 101.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene.[3][4]

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]

Interactions[edit]

PPP2R3A has been shown to interact with CDC6[5] and PPP2R4.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hendrix P, Mayer-Jackel RE, Cron P, Goris J, Hofsteenge J, Merlevede W, Hemmings BA (Aug 1993). "Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing". J Biol Chem. 268 (20): 15267–76. PMID 8392071. 
  4. ^ a b "Entrez Gene: PPP2R3A protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha". 
  5. ^ a b Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (Jun 2008). "Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit". J. Biol. Chem. United States. 283 (23): 16104–14. doi:10.1074/jbc.M710313200. ISSN 0021-9258. PMC 2414307Freely accessible. PMID 18397887. 

Further reading[edit]