PUF60

PUF60
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DNY, 2KXF, 2KXH, 2QFJ, 3DXB, 3UE2, 3US5, 3UWT
Identifiers
Aliases	PUF60, FIR, RoBPI, SIAHBP1, VRJS, poly(U) binding splicing factor 60KDa, poly(U) binding splicing factor 60
External IDs	OMIM: 604819; MGI: 1915209; HomoloGene: 8614; GeneCards: PUF60; OMA:PUF60 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,829,352 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	75,952,773 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; right uterine tube; ; ganglionic eminence; ; tibial nerve; ; prefrontal cortex; ; substantia nigra; ; C1 segment; ; skin of leg; ; apex of heart; ; putamen;
	Top expressed in
	mandibular prominence; ; maxillary prominence; ; somite; ; Gonadal ridge; ; neural layer of retina; ; vestibular sensory epithelium; ; supraoptic nucleus; ; ventricular zone; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA binding; protein binding; identical protein binding; RNA binding; cadherin binding;
Cellular component	cell junction; cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleus; nucleoplasm;
Biological process	mRNA processing; regulation of transcription, DNA-templated; transcription, DNA-templated; RNA splicing; apoptotic process; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	22827
	67959
	ENSG00000179950; ENSG00000274081
	ENSMUSG00000002524
	Q9UHX1
	Q3UEB3
NM_001136033; NM_001271096; NM_001271097; NM_001271098; NM_001271099;
	NM_001271100; NM_014281; NM_078480; NM_001362895; NM_001362896; NM_001362897
NM_001164600; NM_028364; NM_133691; NM_001356629; NM_001378984;
	NM_001378985; NM_001378986
NP_001129505; NP_001258025; NP_001258026; NP_001258027; NP_001258028;
	NP_001258029; NP_055096; NP_510965; NP_001349824; NP_001349825; NP_001349826
NP_001158072; NP_082640; NP_598452; NP_001343558; NP_001365913;
	NP_001365914; NP_001365915; NP_001389972; NP_001389973; NP_001389974; NP_001389975
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the PUF60 gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

Interactions

PUF60 has been shown to interact with U2AF2.^[9]^[10]

References

^ ^a ^b ^c ENSG00000274081 GRCh38: Ensembl release 89: ENSG00000179950, ENSG00000274081 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002524 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bouffard P, Barbar E, Briere F, Boire G (Feb 2000). "Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins". RNA. 6 (1): 66–78. doi:10.1017/S1355838200990277. PMC 1369894. PMID 10668799.
^ Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D (Jul 2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
^ Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR (Jun 2007). Valcarcel J (ed.). "Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65". PLoS ONE. 2 (6): e538. Bibcode:2007PLoSO...2..538H. doi:10.1371/journal.pone.0000538. PMC 1888729. PMID 17579712.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: SIAHBP1 fuse-binding protein-interacting repressor".
^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laysource=, and |laydate= (help)
^ Ewing, Rob M; Chu Peter; Elisma Fred; Li Hongyan; Taylor Paul; Climie Shane; McBroom-Cerajewski Linda; Robinson Mark D; O'Connor Liam; Li Michael; Taylor Rod; Dharsee Moyez; Ho Yuen; Heilbut Adrian; Moore Lynda; Zhang Shudong; Ornatsky Olga; Bukhman Yury V; Ethier Martin; Sheng Yinglun; Vasilescu Julian; Abu-Farha Mohamed; Lambert Jean-Philippe; Duewel Henry S; Stewart Ian I; Kuehl Bonnie; Hogue Kelly; Colwill Karen; Gladwish Katharine; Muskat Brenda; Kinach Robert; Adams Sally-Lin; Moran Michael F; Morin Gregg B; Topaloglou Thodoros; Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1). England: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laysource=, and |laydate= (help)

Interactions

References

Further reading