Paper spray ionization
Paper spray ionization is a technique used in mass spectrometry to produce ions from a sample to be analyzed. It is a variant of electrospray ionization.[1] The sample (for instance a few microlitres of blood or urine) is applied to a piece of paper and solvent is added. Then a high voltage is applied, which creates the ions to be analyzed with a mass spectrometer. The method, first described in 2010,[2] is relatively easy to use and can detect and measure the presence of various substances in the sample, for instance in clinical applications.
In 2017 it was reported that a test based on paper spray ionization mass spectrometry can detect cocaine use from a subject's fingerprint.[3]
References
- ^ Meher, Anil Kumar; Chen, Yu-Chie (2017). "Electrospray Modifications for Advancing Mass Spectrometric Analysis". Mass Spectrometry. 6 (Spec Iss). doi:10.5702/massspectrometry.S0057. PMC 5448333. PMID 28573082.
- ^ Liu, Jiangjiang; Wang, He; Manicke, Nicholas E.; Lin, Jin-Ming; Cooks, R. Graham; Ouyang, Zheng (2010-03-15). "Development, characterization, and application of paper spray ionization". Analytical Chemistry. 82 (6): 2463–2471. doi:10.1021/ac902854g. PMID 20158226.
- ^ Glatter, Robert (September 23, 2017). "New Fingerprint Test Can Detect Cocaine Use In Seconds". Forbes.
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| Ion source | |
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| Mass analyzer | |
| Detector | |
| MS combination | |
| Fragmentation | |
