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Phenylpyruvate decarboxylase

From Wikipedia, the free encyclopedia
phenylpyruvate decarboxylase
Identifiers
EC no.4.1.1.43
CAS no.37289-45-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme phenylpyruvate decarboxylase (EC 4.1.1.43) catalyzes the chemical reaction

phenylpyruvate phenylacetaldehyde + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming). This enzyme is also called phenylpyruvate carboxy-lyase.[citation needed] This enzyme participates in phenylalanine and tryptophan metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2NXW.

References

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  • Asakawa T, Wada H, Yamano T (1968). "Enzymatic conversion of phenylpyruvate to phenylacetate". Biochim. Biophys. Acta. 170 (2): 375–91. doi:10.1016/0304-4165(68)90017-2. PMID 4303395.