QKI

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QKI
Protein QKI PDB 2bl5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding
External IDs MGI: 97837 HomoloGene: 11059 GeneCards: QKI
RNA expression pattern
PBB GE QKI 212636 at fs.png

PBB GE QKI 214541 s at fs.png

PBB GE QKI 212263 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301085
NM_006775
NM_206853
NM_206854
NM_206855

NM_001159516
NM_001159517
NM_021881

RefSeq (protein)

NP_001288014
NP_006766
NP_996735
NP_996736
NP_996737

NP_001152988
NP_001152989
NP_068681

Location (UCSC) Chr 6: 163.41 – 163.58 Mb Chr 17: 10.21 – 10.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.[3][4]

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.[5] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 .[6] Two more new members are KHDRBS3[7] and KHDRBS2.[8]

The QKI gene is implicated as being important in schizophrenia,[9][10] and QKI controls translation of many oligodendrocyte-related genes.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)". 
  4. ^ Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB (October 1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. PMC 23011Freely accessible. PMID 10535969. doi:10.1073/pnas.96.22.12605. 
  5. ^ Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84. PMID 9433137. doi:10.1016/S0168-9525(97)01269-9. 
  6. ^ Chen T, Richard S (August 1998). "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization". Mol. Cell. Biol. 18 (8): 4863–71. PMC 109071Freely accessible. PMID 9671495. 
  7. ^ Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (June 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. PMID 10332027. doi:10.1093/hmg/8.6.959. 
  8. ^ Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75. PMID 12549823. doi:10.1023/A:1021246109101. 
  9. ^ Aberg K, Saetre P, Jareborg N, Jazin E (May 2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. PMC 1464365Freely accessible. PMID 16641098. doi:10.1073/pnas.0601213103. 
  10. ^ Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7. PMID 17012699. doi:10.1176/ajp.2006.163.10.1834. 

Further reading[edit]