RAE1

RAE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MMY, 4OWR
Identifiers
Aliases	RAE1, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1, Gle2
External IDs	OMIM: 603343; MGI: 1913929; HomoloGene: 2676; GeneCards: RAE1; OMA:RAE1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,379,211 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,857,532 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; left testis; ; right testis; ; tendon of biceps brachii; ; internal globus pallidus; ; embryo; ; trabecular bone; ; ganglionic eminence; ; bone marrow;
	Top expressed in
	otic placode; ; spermatocyte; ; saccule; ; otic vesicle; ; spermatid; ; epiblast; ; zygote; ; embryo; ; mandibular prominence; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; RNA binding; protein binding; ubiquitin binding;
Cellular component	cytoplasm; nuclear pore; nucleus; nuclear envelope; fibrillar center; mitotic spindle pole; spindle pole; cytoskeleton; host cell;
Biological process	cellular response to organic cyclic compound; viral process; regulation of mitotic spindle organization; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; RNA export from nucleus; protein import into nucleus; cell cycle; cell division; mRNA export from nucleus; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	8480
	66679
	ENSG00000101146
	ENSMUSG00000027509
	P78406
	Q8C570
	NM_001015885; NM_003610
	NM_175112
	NP_001015885; NP_003601
	NP_780321
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA export factor is a protein that in humans is encoded by the RAE1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

RAE1 has been shown to interact with NUP98.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101146 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027509 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bharathi A, Ghosh A, Whalen WA, Yoon JH, Pu R, Dasso M, Dhar R (Dec 1997). "The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA". Gene. 198 (1–2): 251–8. doi:10.1016/S0378-1119(97)00322-3. PMID 9370289.
^ Kraemer D, Blobel G (Sep 1997). "mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm". Proc Natl Acad Sci U S A. 94 (17): 9119–24. Bibcode:1997PNAS...94.9119K. doi:10.1073/pnas.94.17.9119. PMC 23064. PMID 9256445.
^ "Entrez Gene: RAE1 RAE1 RNA export 1 homolog (S. pombe)".
^ Pritchard, C E; Fornerod M; Kasper L H; van Deursen J M (Apr 1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. 145 (2). UNITED STATES: 237–54. doi:10.1083/jcb.145.2.237. ISSN 0021-9525. PMC 2133102. PMID 10209021. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading