RAP1GDS1

RAP1GDS1
Identifiers
Aliases	RAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDs	OMIM: 179502; MGI: 2385189; HomoloGene: 41422; GeneCards: RAP1GDS1; OMA:RAP1GDS1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	98,443,861 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	138,780,962 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pons; ; pars compacta; ; trigeminal ganglion; ; pars reticulata; ; middle temporal gyrus; ; spinal ganglia; ; superior vestibular nucleus; ; sperm; ; corpus callosum;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; perirhinal cortex; ; inferior colliculi; ; olfactory epithelium; ; visual cortex; ; pontine nuclei; ; primary motor cortex; ; CA3 field;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	cytosol; extracellular exosome; endoplasmic reticulum; mitochondrion;
Biological process	negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of mitochondrial calcium ion concentration; vascular associated smooth muscle contraction; myosin filament assembly; small GTPase mediated signal transduction; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	5910
	229877
	ENSG00000138698
	ENSMUSG00000028149
	P52306
	E9Q912
NM_001100426; NM_001100427; NM_001100428; NM_001100429; NM_001100430;
	NM_021159
	NM_001040690; NM_001286759; NM_145544; NM_001356388
NP_001093896; NP_001093897; NP_001093898; NP_001093899; NP_001093900;
	NP_066982
	NP_001035780; NP_001273688; NP_001343317; NP_663519
	Wikidata
View/Edit Human	View/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

RAP1GDS1 has been shown to interact with KIFAP3,^[8] HRAS^[9] and RHOA.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138698 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526.
^ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
^ Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43). UNITED STATES: 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ ^a ^b Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15). England: 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

Interactions

References

Further reading