RDH12

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RDH12
Identifiers
Aliases RDH12, LCA13, LCA3, RP53, SDR7C2, retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
External IDs MGI: 1925224 HomoloGene: 110830 GeneCards: RDH12
RNA expression pattern
PBB GE RDH12 gnf1h02839 s at fs.png

PBB GE RDH12 gnf1h06304 at fs.png

PBB GE RDH12 gnf1h08075 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152443

NM_030017
NM_001313971

RefSeq (protein)

NP_689656

NP_001300900.1
NP_084293.1
NP_001300900
NP_084293

Location (UCSC) Chr 14: 67.7 – 67.73 Mb Chr 12: 79.21 – 79.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Retinol dehydrogenase 12 is an enzyme that in humans is encoded by the RDH12 gene.[3][4][5]

Retinoids are indispensable light-sensitive elements of vision and also serve as essential modulators of cellular differentiation and proliferation in diverse cell types. RDH12 belongs to a family of dual-specificity retinol dehydrogenases that metabolize both all-trans- and cis-retinols (Haeseleer et al., 2002).[supplied by OMIM][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem. 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693Freely accessible. PMID 12226107. 
  4. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744Freely accessible. PMID 19027726. 
  5. ^ a b "Entrez Gene: RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)". 

Further reading[edit]