RGS12

RGS12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBZ, 2KV8
Identifiers
Aliases	RGS12, regulator of G protein signaling 12
External IDs	OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,439,913 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,196,988 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; mucosa of esophagus; ; skin of leg; ; right uterine tube; ; skin of abdomen; ; right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; ectocervix;
	Top expressed in
	spermatocyte; ; lip; ; hand; ; ventricular zone; ; genital tubercle; ; Rostral migratory stream; ; spermatid; ; ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase regulator activity; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; cell projection; nuclear matrix; synapse; condensed nuclear chromosome; cell junction; dendrite; plasma membrane; nucleus; nucleolus; cytosol;
Biological process	regulation of G protein-coupled receptor signaling pathway; transcription, DNA-templated; positive regulation of GTPase activity; negative regulation of signal transduction; signal transduction; regulation of catalytic activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6002
	71729
	ENSG00000159788
	ENSMUSG00000029101
	O14924
	Q8CGE9
NM_002926; NM_198227; NM_198229; NM_198230; NM_198430;
	NM_198432; NM_198587; NM_001394154; NM_001394155; NM_001394156; NM_001394157; NM_001394158; NM_001394159; NM_001394161; NM_001394162; NM_001394163
	NM_001163512; NM_173402
	NP_002917; NP_937870; NP_937872
NP_001156984; NP_775578; NP_001390400; NP_001390401; NP_001390402;
	NP_001390403; NP_001390404; NP_001390405; NP_001390406; NP_001390407
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[5]^[6]

Template:PBB Summary

Interactions

RGS12 has been shown to interact with GNAI1^[7] and GNAI3.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: RGS12 regulator of G-protein signalling 12".
^ ^a ^b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31). United States: 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading