RHOQ

RHOQ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ATX
Identifiers
Aliases	RHOQ, ARHQ, HEL-S-42, RASL7A, TC10, TC10A, ras homolog family member Q
External IDs	OMIM: 605857; MGI: 1931553; HomoloGene: 22704; GeneCards: RHOQ; OMA:RHOQ - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,584,688 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,307,497 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; Achilles tendon; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; thoracic diaphragm; ; cardiac muscle tissue of right atrium; ; Epithelium of choroid plexus; ; muscle of thigh;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; ankle; ; digastric muscle; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GBD domain binding; profilin binding; nucleotide binding; GTP binding; GTPase activity; protein kinase binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; actin filament; membrane raft; Golgi-associated vesicle membrane; extracellular exosome; intracellular anatomical structure; cell cortex; cell projection;
Biological process	positive regulation of glucose import; insulin receptor signaling pathway; regulation of actin cytoskeleton organization; regulation of cell shape; cellular response to insulin stimulus; regulation of small GTPase mediated signal transduction; cortical actin cytoskeleton organization; positive regulation of filopodium assembly; positive regulation of transcription by RNA polymerase II; GTP metabolic process; small GTPase mediated signal transduction; negative regulation of protein localization to plasma membrane; endocytosis; actin filament organization; establishment or maintenance of cell polarity; Rho protein signal transduction; cell projection assembly; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	23433
	104215
	ENSG00000119729
	ENSMUSG00000024143
	P17081
	Q8R527
	NM_012249
	NM_145491
	NP_036381
	NP_663466
	Wikidata
View/Edit Human	View/Edit Mouse

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.^[5]^[6]

Template:PBB Summary

Interactions

RHOQ has been shown to interact with EXOC7,^[7] GOPC,^[8] PARD6B,^[8]^[9] WASL,^[10] CDC42EP2,^[11] TRIP10^[12] and CDC42EP3.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119729 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024143 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol. 10 (4): 1793–8. PMC 362288. PMID 2108320.
^ "Entrez Gene: RHOQ ras homolog gene family, member Q".
^ Inoue, Mayumi; Chang Louise; Hwang Joseph; Chiang Shian-Huey; Saltiel Alan R (April 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature. 422 (6932). England: 629–33. doi:10.1038/nature01533. ISSN 0028-0836. PMID 12687004.
^ ^a ^b Neudauer, C L; Joberty G; Macara I G (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2). United States: 541–7. doi:10.1006/bbrc.2000.4160. ISSN 0006-291X. PMID 11162552.
^ Joberty, G; Petersen C; Gao L; Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8). ENGLAND: 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474.
^ Abe, Tomoyuki; Kato Masayoshi; Miki Hiroaki; Takenawa Tadaomi; Endo Takeshi (January 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell. Sci. 116 (Pt 1). England: 155–68. doi:10.1242/jcs.00208. ISSN 0021-9533. PMID 12456725.
^ ^a ^b Joberty, G; Perlungher R R; Macara I G (October 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. 19 (10). UNITED STATES: 6585–97. ISSN 0270-7306. PMC 84628. PMID 10490598.
^ Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20). United States: 12835–40. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347.

Interactions

References

Further reading