RIC8A

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RIC8A
Identifiers
Aliases RIC8A, RIC8, RIC8 guanine nucleotide exchange factor A
External IDs MGI: 2141866 HomoloGene: 23331 GeneCards: RIC8A
RNA expression pattern
PBB GE RIC8A 221647 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286134
NM_021932

NM_053194

RefSeq (protein)

NP_001273063
NP_068751

NP_444424.1
NP_444424

Location (UCSC) Chr 11: 0.21 – 0.22 Mb Chr 7: 140.86 – 140.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Synembryn-A is a protein that in humans is encoded by the RIC8A gene.[3][4][5]


Interactions[edit]

RIC8A has been shown to interact with GNAO1,[6] GNA13,[6] GNAQ,[6][7] GNAS complex locus,[7] GNAI2,[6] GNAI1[6] and GNAI3.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Miller KG, Emerson MD, McManus JR, Rand JB (Sep 2000). "RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system". Neuron. 27 (2): 289–99. doi:10.1016/S0896-6273(00)00037-4. PMID 10985349. 
  4. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072Freely accessible. PMID 11230166. 
  5. ^ "Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)". 
  6. ^ a b c d e f Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. United States. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  7. ^ a b Klattenhoff, Carla; Montecino Martín; Soto Ximena; Guzmán Leonardo; Romo Ximena; García María Angeles; Mellstrom Britt; Naranjo José Ramón; Hinrichs María Victoria; Olate Juan (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. United States. 195 (2): 151–7. doi:10.1002/jcp.10300. ISSN 0021-9541. PMID 12652642. 

Further reading[edit]