RNF2

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RNF2
Protein RNF2 PDB 2ckl.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF2, BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2
External IDsMGI: 1101759 HomoloGene: 2199 GeneCards: RNF2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RNF2
Genomic location for RNF2
Band1q25.3Start185,045,364 bp[1]
End185,102,608 bp[1]
RNA expression pattern
PBB GE RNF2 205215 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007212

NM_011277
NM_001360844
NM_001360845
NM_001360847

RefSeq (protein)

NP_009143

NP_035407
NP_001347773
NP_001347774
NP_001347776

Location (UCSC)Chr 1: 185.05 – 185.1 MbChr 1: 151.46 – 151.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.[5][6]

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.[6]

Interactions[edit]

RNF2 has been shown to interact with TFCP2[7] and HIP2.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121481 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026484 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. 
  6. ^ a b "Entrez Gene: RNF2 ring finger protein 2". 
  7. ^ Tuckfield, Annabel; Clouston David R; Wilanowski Tomasz M; Zhao Lin-Lin; Cunningham John M; Jane Stephen M (March 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. United States. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. ISSN 0270-7306. PMC 135618Freely accessible. PMID 11865070. 

Further reading[edit]

External links[edit]