RNF2

RNF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H0D, 3GS2, 3H8H, 3IXS, 3RPG, 4R8P, 4S3O
Identifiers
Aliases	RNF2, BAP-1, BAP1, DING, HIPI3, RING1B, RING2, ring finger protein 2, ring1B, LUSYAM
External IDs	OMIM: 608985; MGI: 1101759; HomoloGene: 2199; GeneCards: RNF2; OMA:RNF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	185,102,603 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	151,376,706 bp
RNA expression pattern
	Top expressed in
	gonad; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; stromal cell of endometrium; ; testicle; ; monocyte; ; Achilles tendon; ; epithelium of colon; ; buccal mucosa cell;
	Top expressed in
	genital tubercle; ; zygote; ; tail of embryo; ; medial ganglionic eminence; ; secondary oocyte; ; Gonadal ridge; ; mandibular prominence; ; atrioventricular valve; ; maxillary prominence; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; chromatin binding; RING-like zinc finger domain binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; transferase activity; zinc ion binding;
Cellular component	euchromatin; sex chromatin; ubiquitin ligase complex; nucleoplasm; chromosome; heterochromatin; MLL1 complex; PRC1 complex; PcG protein complex; nucleus; nuclear body;
Biological process	germ cell development; histone H2A-K119 monoubiquitination; regulation of transcription, DNA-templated; gastrulation with mouth forming second; histone H2A monoubiquitination; negative regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; protein ubiquitination; mitotic cell cycle; anterior/posterior axis specification; histone ubiquitination; negative regulation of G0 to G1 transition;
	Sources:Amigo / QuickGO
Orthologs
	6045
	19821
	ENSG00000121481
	ENSMUSG00000026484
	Q99496
	Q9CQJ4
	NM_007212
	NM_011277; NM_001360844; NM_001360845; NM_001360847
	NP_009143
	NP_035407; NP_001347773; NP_001347774; NP_001347776
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.^[5]^[6]

Template:PBB Summary

Interactions

RNF2 has been shown to interact with TFCP2^[7] and HIP2.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121481 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026484 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.
^ "Entrez Gene: RNF2 ring finger protein 2".
^ Tuckfield, Annabel; Clouston David R; Wilanowski Tomasz M; Zhao Lin-Lin; Cunningham John M; Jane Stephen M (March 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. 22 (6). United States: 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. ISSN 0270-7306. PMC 135618. PMID 11865070. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

RNF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Template:PBB Controls

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121481 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026484 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11513855-5] Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.

[entrez-6] "Entrez Gene: RNF2 ring finger protein 2".

[pmid11865070-7] Tuckfield, Annabel; Clouston David R; Wilanowski Tomasz M; Zhao Lin-Lin; Cunningham John M; Jane Stephen M (March 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. 22 (6). United States: 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. ISSN 0270-7306. PMC 135618. PMID 11865070. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

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RNF2

Interactions

See also

References

Further reading

External links