Rubber cis-polyprenylcistransferase

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rubber cis-polyprenylcistransferase
EC no.
CAS no.62213-41-6
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a rubber cis-polyprenylcistransferase (EC is an enzyme that catalyzes the chemical reaction

poly-cis-polyprenyl diphosphate + isopentenyl diphosphate diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit

Thus, the two substrates of this enzyme are poly-cis-polyprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and poly-cis-polyprenyl diphosphate longer by one C5 unit.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase. Other names in common use include rubber allyltransferase, rubber transferase, isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase, cis-prenyl transferase, rubber polymerase, and rubber prenyltransferase. This enzyme participates in biosynthesis of steroids.


  • Archer BL, Cockbain EG (1969). "Rubber transferase from Hevea brasiliensis latex". Methods Enzymol. Methods in Enzymology. 15: 476–480. doi:10.1016/S0076-6879(69)15018-1. ISBN 978-0-12-181872-2.
  • McMullen AI, McSweeney GP (October 1966). "The biosynthesis of rubber: Incorporation of isopentenyl pyrophosphate into purified rubber particles by a soluble latex serum enzyme". The Biochemical Journal. 101 (1): 42–7. PMC 1270063. PMID 16742418.