SENP2

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SENP2
Protein SENP2 PDB 1tgz.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SENP2, AXAM2, SMT3IP2, SUMO1/sentrin/SMT3 specific peptidase 2
External IDs MGI: 1923076 HomoloGene: 11005 GeneCards: SENP2
RNA expression pattern
PBB GE SENP2 218122 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021627

NM_029457

RefSeq (protein)

NP_067640

NP_083733.1
NP_083733

Location (UCSC) Chr 3: 185.58 – 185.63 Mb Chr 16: 22.01 – 22.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.[3][4][5]

Function[edit]

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM][5]

Interactions[edit]

SENP2 has been shown to interact with NUP153.[3][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Hang J, Dasso M (May 2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore". J. Biol. Chem. 277 (22): 19961–6. doi:10.1074/jbc.M201799200. PMID 11896061. 
  4. ^ Nishida T, Kaneko F, Kitagawa M, Yasuda H (October 2001). "Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation". J. Biol. Chem. 276 (42): 39060–6. doi:10.1074/jbc.M103955200. PMID 11489887. 
  5. ^ a b "Entrez Gene: SENP2 SUMO1/sentrin/SMT3 specific peptidase 2". 
  6. ^ Zhang H, Saitoh H, Matunis MJ (September 2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. 22 (18): 6498–508. doi:10.1128/MCB.22.18.6498-6508.2002. PMC 135644Freely accessible. PMID 12192048. 

Further reading[edit]