SH3KBP1

SH3KBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BZ8, 2K6D, 2K9G, 2O2O, 2YDL, 5ABS, 2N64
Identifiers
Aliases	SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
External IDs	OMIM: 300374; MGI: 1889583; HomoloGene: 10971; GeneCards: SH3KBP1; OMA:SH3KBP1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	19,887,600 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	158,761,065 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; blood; ; monocyte; ; bone marrow cells; ; ventral tegmental area; ; pancreatic ductal cell; ; trabecular bone; ; medulla oblongata;
	Top expressed in
	thymus; ; myocardium of ventricle; ; right ventricle; ; cardiac muscles; ; atrioventricular valve; ; secondary oocyte; ; extraocular muscle; ; spleen; ; cumulus cell; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; protein binding;
Cellular component	cytosol; membrane; cell-cell junction; focal adhesion; plasma membrane; endocytic vesicle; synapse; cell junction; neuron projection; cytoskeleton; cytoplasmic vesicle membrane; cytoplasmic vesicle; cytoplasm;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; endocytosis; cell-cell signaling; cytoskeleton organization; regulation of cell shape; cell migration; apoptotic process; membrane organization; axon guidance; actin filament organization;
	Sources:Amigo / QuickGO
Orthologs
	30011
	58194
	ENSG00000147010
	ENSMUSG00000040990
	Q96B97; Q5JPT2
	Q8R550
NM_001024666; NM_001184960; NM_031892; NM_001353890; NM_001353891;
	NM_001353892; NM_001353893; NM_001353894; NM_001353895; NM_001353897
NM_001135727; NM_001135728; NM_001290661; NM_001290664; NM_021389;
	NM_001374701
NP_001019837; NP_001171889; NP_114098; NP_001340819; NP_001340820;
	NP_001340821; NP_001340822; NP_001340823; NP_001340824; NP_001340826
NP_001129199; NP_001129200; NP_001277590; NP_001277593; NP_067364;
	NP_001361630
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.^[5]^[6]

Template:PBB Summary

Interactions

SH3KBP1 has been shown to interact with B-cell linker,^[7] Grb2,^[8]^[9] SH3GLB2,^[10]^[11] SH3GL3,^[10] SH3GL2,^[11] BCAR1,^[7] Epidermal growth factor receptor,^[11]^[12] CBLB,^[12] Cbl gene,^[7]^[9]^[10]^[11]^[12] SOS1,^[7] CRK^[7] and PAK2.^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147010 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040990 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hillier LD; Lennon G; Becker M; Bonaldo MF; Chiapelli B; Chissoe S; Dietrich N; DuBuque T; Favello A; Gish W; Hawkins M; Hultman M; Kucaba T; Lacy M; Le M; Le N; Mardis E; Moore B; Morris M; Parsons J; Prange C; Rifkin L; Rohlfing T; Schellenberg K; Bento Soares M; Tan F; Thierry-Meg J; Trevaskis E; Underwood K; Wohldman P; Waterston R; Wilson R; Marra M (May 1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
^ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O, et al. (November 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
^ ^a ^b ^c ^d ^e Watanabe, S; Take H; Takeda K; Yu Z X; Iwata N; Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. Res. Commun. 278 (1). UNITED STATES: 167–74. doi:10.1006/bbrc.2000.3760. ISSN 0006-291X. PMID 11071869.
^ Gout, I; Middleton G; Adu J; Ninkina N N; Drobot L B; Filonenko V; Matsuka G; Davies A M; Waterfield M; Buchman V L (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". EMBO J. 19 (15). ENGLAND: 4015–25. doi:10.1093/emboj/19.15.4015. ISSN 0261-4189. PMC 306608. PMID 10921882.
^ ^a ^b Borinstein, S C; Hyatt M A; Sykes V W; Straub R E; Lipkowitz S; Boulter J; Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. Signal. 12 (11–12). ENGLAND: 769–79. doi:10.1016/S0898-6568(00)00129-7. ISSN 0898-6568. PMID 11152963.
^ ^a ^b ^c Petrelli, Annalisa; Gilestro Giorgio F; Lanzardo Stefania; Comoglio Paolo M; Migone Nicola; Giordano Silvia (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877). England: 187–90. doi:10.1038/416187a. ISSN 0028-0836. PMID 11894096.
^ ^a ^b ^c ^d Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877). England: 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095.
^ ^a ^b ^c Szymkiewicz, Iwona; Kowanetz Katarzyna; Soubeyran Philippe; Dinarina Ana; Lipkowitz Stanley; Dikic Ivan (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42). United States: 39666–72. doi:10.1074/jbc.M205535200. ISSN 0021-9258. PMID 12177062.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Kurakin, Alexei V; Wu Susan; Bredesen Dale E (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". J. Biol. Chem. 278 (36). United States: 34102–9. doi:10.1074/jbc.M305264200. ISSN 0021-9258. PMID 12829691.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading