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Aliases STC2, STC-2, STCRP, stanniocalcin 2
External IDs MGI: 1316731 HomoloGene: 2753 GeneCards: STC2
RNA expression pattern
PBB GE STC2 203439 s at fs.png

PBB GE STC2 203438 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 173.31 – 173.33 Mb Chr 11: 31.36 – 31.37 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Stanniocalcin-2 is a protein that in humans is encoded by the STC2 gene.[3][4][5]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chang AC, Reddel RR (Nov 1998). "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2". Mol Cell Endocrinol. 141 (1–2): 95–9. doi:10.1016/S0303-7207(98)00097-5. PMID 9723890. 
  4. ^ Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M (Nov 1998). "Molecular cloning of a second human stanniocalcin homologue (STC2)". Biochem Biophys Res Commun. 250 (2): 252–8. doi:10.1006/bbrc.1998.9300. PMID 9753616. 
  5. ^ a b "Entrez Gene: STC2 stanniocalcin 2". 

Further reading[edit]