SUFU

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SUFU
Protein SUFU PDB 1m1l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling
External IDs MGI: 1345643 HomoloGene: 9262 GeneCards: SUFU
RNA expression pattern
PBB GE SUFU gnf1h00213 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001178133
NM_016169

NM_001025391
NM_015752

RefSeq (protein)

NP_001171604
NP_057253

NP_001020562.1
NP_056567.2
NP_001020562
NP_056567

Location (UCSC) Chr 10: 102.5 – 102.63 Mb Chr 19: 46.4 – 46.49 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene.[3][4]

Function[edit]

SUFU encodes a component of the sonic hedgehog (SHH) / patched (PTCH) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., holoprosencephaly, HPE3; basal cell nevus syndrome, BCNS; and Greig cephalopolysyndactyly syndrome; GCPS).[4]

Interactions[edit]

SUFU has been shown to interact with GLI1,[5][6][7] GLI3[8] and PEX26.[9]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Merchant M, Vajdos FF, Ultsch M, Maun HR, Wendt U, Cannon J, Desmarais W, Lazarus RA, de Vos AM, de Sauvage FJ (Sep 2004). "Suppressor of fused regulates Gli activity through a dual binding mechanism". Mol Cell Biol. 24 (19): 8627–41. doi:10.1128/MCB.24.19.8627-8641.2004. PMC 516763Freely accessible. PMID 15367681. 
  4. ^ a b "Entrez Gene: SUFU suppressor of fused homolog (Drosophila)". 
  5. ^ Stone DM, Murone M, Luoh S, Ye W, Armanini MP, Gurney A, Phillips H, Brush J, Goddard A, de Sauvage FJ, Rosenthal A (December 1999). "Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli". J. Cell. Sci. 112 (23): 4437–48. PMID 10564661. 
  6. ^ Kogerman P, Grimm T, Kogerman L, Krause D, Undén AB, Sandstedt B, Toftgård R, Zaphiropoulos PG (September 1999). "Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1". Nat. Cell Biol. 1 (5): 312–9. doi:10.1038/13031. PMID 10559945. 
  7. ^ Dunaeva M, Michelson P, Kogerman P, Toftgard R (February 2003). "Characterization of the physical interaction of Gli proteins with SUFU proteins". J. Biol. Chem. 278 (7): 5116–22. doi:10.1074/jbc.M209492200. PMID 12426310. 
  8. ^ Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R (April 2010). "The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins". Genes Dev. 24 (7): 670–82. doi:10.1101/gad.1902910. PMC 2849124Freely accessible. PMID 20360384. 
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]