Phenyl salicylate

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Phenyl salicylate[1]
Skeletal formula
Ball-and-stick model
IUPAC name
Phenyl 2-hydroxybenzoate
Other names
3D model (JSmol)
ECHA InfoCard 100.003.873
EC Number 204-259-2
MeSH C026041
Molar mass 214.22 g/mol
Appearance White solid
Density 1.25 g/cm3
Melting point 41.5 °C (106.7 °F; 314.6 K)
Boiling point 173 °C (343 °F; 446 K) at 12 mmHg
1 g/6670 mL
-123.2·10−6 cm3/mol
G04BX12 (WHO)
Flash point 137.3[2] °C (279.1 °F; 410.4 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phenyl salicylate, or salol, is a chemical substance, introduced in 1886 by Marceli Nencki of Basel. It can be created by heating salicylic acid with phenol. Once used in sunscreens, phenyl salicylate is now used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes.[1] It is also used frequently in school laboratory demonstrations on how cooling rates affect crystal size in igneous rocks.

Salol reaction[edit]

In the salol reaction, phenyl salicylate reacts with o-toluidine in 1,2,4-trichlorobenzene at elevated temperatures to the corresponding amide o-Salicylotoluide.[3] Salicylamides are one type of drug.


It has been used as an antiseptic[4] based on the antibacterial activity upon hydrolysis in the small intestine.[citation needed]

It acts as a mild analgesic.[5]


  1. ^ a b Merck Index, 11th Edition, 7282.
  2. ^ a b ChemBK Chemical Database
  3. ^ Allen, C. F. H.; VanAllan, J. (1946). "SALICYL-o-TOLUIDE" (PDF). Org. Synth. 26: 92. ; Coll. Vol., 3, p. 765 
  4. ^ Walter Sneader (2005). Drug discovery: a history. John Wiley and Sons. pp. 358–. ISBN 978-0-471-89980-8. Retrieved 28 October 2010. 
  5. ^ Judith Barberio (4 September 2009). Nurse's Pocket Drug Guide, 2010. McGraw Hill Professional. pp. 57–. ISBN 978-0-07-162743-6. Retrieved 28 October 2010.