Sarcosine/dimethylglycine N-methyltransferase
| Sarcosine/dimethylglycine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.157 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sarcosine/dimethylglycine N-methyltransferase (EC 2.1.1.157, ApDMT, sarcosine-dimethylglycine methyltransferase, SDMT, sarcosine dimethylglycine N-methyltransferase, S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase (N,N-dimethylglycine(or betaine)-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + sarcosine 2 S-adenosyl-L-homocysteine + betaine (overall reaction)
- (1a) S-adenosyl-L-methionine + sarcosine S-adenosyl-L-homocysteine + N,N-dimethylglycine
- (1b) S-adenosyl-L-methionine + N,N-dimethylglycine S-adenosyl-L-homocysteine + betaine
This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.
References
- ^ Nyyssölä, A.; Kerovuo, J.; Kaukinen, P.; von Weymarn, N.; Reinikainen, T. (2000). "Extreme halophiles synthesize betaine from glycine by methylation". J. Biol. Chem. 275 (29): 22196–22201. doi:10.1074/jbc.M910111199. PMID 10896953.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Nyyssölä, A.; Reinikainen, T.; Leisola, M. (2001). "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase". Appl. Environ. Microbiol. 67 (5): 2044–2050. doi:10.1128/AEM.67.5.2044-2050.2001. PMC 92834. PMID 11319079.
- ^ Waditee, R.; Tanaka, Y.; Aoki, K.; Hibino, T.; Jikuya, H.; Takano, J.; Takabe, T.; Takabe, T. (2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". J. Biol. Chem. 278 (7): 4932–4942. doi:10.1074/jbc.M210970200. PMID 12466265.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- Sarcosine/dimethylglycine+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)