He began his career contributing to the alternative comics review Deadline Magazine in the 1980s (where he created Fatal Charm with D'Israeli). In 1989 Shane worked as the penciller on issues 1 to 6 of Mister X volume two. Since then Shane has contributed to several anthology titles, such as Negative Burn and The Big Book of Urban Legends, even drawing an issue of Neil Gaiman's legendary Sandman.
Oakley is probably best known for his co-creation of the Wildstorm mini series Albion, with Alan Moore, Leah Moore, and John Reppion which ran from 2005 until 2006. The series revived many long forgotten UK comic book characters such as the Steel Claw and Grimly Feendish, some of whom had not been in print since the 1950s.
Boom! Studios' Cthulhu Tales #2 (published April 2008) featured a story entitled The Hiding Place written by Steve Niles and illustrated by Oakley. Shane has also provided covers for several issues of Cthulhu Tales and Zombie Tales.
- Albion (plotted by Alan Moore, written by Leah Moore/John Reppion, Wildstorm, tpb ISBN 1-4012-0994-7)
- "The Fall of the House of Usher" (with Dan Whitehead, in Nevermore, Self Made Hero, ISBN 0-9552856-8-2)
- Channel Evil (with Alan Grant, 4-issue mini-series, Berserker Comics/Renegade Arts Entertainment, 2009)
- Channel Evil at Renegade Arts Entertainment