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Shō-saiko-tō (小柴胡湯), also known as minor bupuleurum formula and xiǎocháihútāng (XCHT) (Chinese: 小柴胡湯), is a herbal supplement, believed to enhance liver health. Sho-Saiko-To is a widely used prescription drug in China and is a listed formula in China and Japan as a Kampo medicine. There are currently ongoing clinical trials for Sho-Saiko-To at University of California, San Diego and Memorial Sloan-Kettering Cancer Center. The active ingredients of sho-saiko-to discovered so far include baicalin, baicalein, glycyrrhizin, saikosaponins, ginsenosides, wogonin, and gingerol.[citation needed]

As a Chinese patent medicine it is listed in the Pharmacopoeia of the People's Republic of China. One dried, soluble form lists chai-hu/saiko (dried Bupleurum chinense or scorzonerifolium root), huangqin (dry Scutellaria baicalensis stem), banxia (Pinellia ternata), ginger, licorice, jujube, and Codonopsis pilosula as ingredients. This form is standardized to contain at least 20 mg baicalin per serving.[1] Some formulae use ginseng instead of C. pilosula.[2]

It is first recorded in Shanghan Lun c. 220 AD, indicated for "lesser yang".[3][4] It has some antidepressant-like effects.[5][6][7][8]

Sho-saiko-to has been studied, but the results in patients with hepatitis B were very low.[9]


  1. ^ "小柴胡颗粒". 中国药典. Vol. 1. p. 576. ISBN 978-7-5067-7337-9.
  2. ^ 方剂学,段富津主编,上海科学技术出版社,1995.6. ISBN 978-7-5323-3708-8
  3. ^ Zhu, Zhenyu; Zhao, Liang; Liu, Xiaofan; Chen, Jun; Zhang, Hai; Zhang, Guoqing; Chai, Yifeng (August 2010). "Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography–mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats". Journal of Chromatography B. 878 (24): 2184–2190. doi:10.1016/j.jchromb.2010.06.021. PMID 20643590.
  4. ^ DAI, Jie-yu; YANG, Jun-ling; LI, Chuan (September 2008). "Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers". Acta Pharmacologica Sinica. 29 (9): 1086–1093. doi:10.1111/j.1745-7254.2008.00850.x. PMID 18718184.
  5. ^ Li, F. M., & Gao, Z. G. (1996). 90 cases of xiaochaihutang treatment for depression in clinical. Shanxi J.Traditional Chin.Med., 10-11."
  6. ^ Jia et al., 2009 C.X. Jia, K.F. Zhang, L. Yu, G.Q. Sun Antidepressant-like effects of Xiaochaihutang on Post stroke depression in clinical Zhejiang J. Tradit. Chin. Med., 44 (2009), pp. 105–106
  7. ^ Su, Guang Yue; Yang, Jing Yu; Wang, Fang; Ma, Jie; Zhang, Kuo; Dong, Ying Xu; Song, Shao Jiang; Lu, Xiu Mei; Wu, Chun Fu (February 2014). "Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress". Journal of Ethnopharmacology. 152 (1): 217–226. doi:10.1016/j.jep.2014.01.006. PMID 24440317.
  8. ^ Su, Guang Yue; Yang, Jing Yu; Wang, Fang; Xiong, Zhi Li; Hou, Yue; Zhang, Kuo; Song, Cui; Ma, Jie; Song, Shao Jiang; Teng, Huai Feng; Wu, Chun Fu (January 2014). "Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system". Journal of Pharmacy and Pharmacology. 66 (6): 823–34. doi:10.1111/jphp.12201. PMID 24359306. S2CID 20187116.
  9. ^ Kong, De Zhao; Liang, Ning; Yang, Guan Lin; Zhang, Zhe; Liu, Yue; Li, Jing; Liu, Xuehan; Liang, Shibing; Nikolova, Dimitrinka; Jakobsen, Janus C; Gluud, Christian (2019-11-07). Cochrane Hepato-Biliary Group (ed.). "Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B". Cochrane Database of Systematic Reviews. 2019 (11). doi:10.1002/14651858.CD013090.pub2. PMC 6953322. PMID 31697415.

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