"Syrup", pronounced in the song as "sizzurp," is slang for the widely prescribed narcotic medication Phenergan with Codeine (more commonly referred to as its generic formulation promethazine HCl with codeine phosphate). This drug is a cough-suppressing (antitussive), antiemetic syrup used to aid the symptoms of painful, unproductive coughing while also being used to induce sedation, help curb motion sickness and, at one time, even used as a weak antipsychotic (the promethazine). Although the song is mainly expressing the use of promethazine with codeine (see purple drank), there are several other narcotic syrups available that are either alluded to or seen in the music video (i.e. Tussionex (chlorpheniramine and hydrocodone) a gold colored, pineapple flavored extended release narcotic suspension).
A video directed by Jeff Byrd was made for the song, with airtime on MTV and BET. It features an Insane Clown Posse "Amazing Jeckel Brothers" shirt at 1:14, a reference to Three 6 Mafia's longstanding friendship with Psychopathic Records.
The video version censors all references to purple drank, including the chorus, which is rendered as "sippin' on some s*****p".
The main remix, "Sippin' on Some Syrup (Remix)" a.k.a. "Purple Punch", features Dipset rappers Cam'ron, Jim Jones and Juelz Santana. DJ Paul, Juicy J, and Bun B also return with new verses (Pimp C could not return due to his incarceration) and Project Pat's chorus from the original was included. A video of the remix was made, although Cam'ron's verse is removed.