Situs inversus
| Situs inversus | |
|---|---|
| Specialty | Medical genetics  |
Situs inversus (also called situs transversus or oppositus) is a congenital condition in which the major visceral organs are reversed or mirrored from their normal positions. The normal arrangement is known as situs solitus. In other rare cases, in a condition known as situs ambiguus or heterotaxy, situs cannot be determined.
The term situs inversus is a short form of the Latin phrase "situs inversus viscerum," meaning "inverted position of the internal organs." Dextrocardia (the heart being located on the right side of the thorax) was first recognised by Marco Aurelio Severino in 1643. However, situs inversus was first described more than a century later by Matthew Baillie.
The prevalence of situs inversus varies among different populations but is less than 1 in 10,000 people.[1]
Effect on anatomy
The condition affects all major structures within the thorax and abdomen. Generally, the organs are simply transposed through the sagittal plane. The heart is located on the right side of the thorax, the stomach and spleen on the right side of the abdomen and the liver and gall bladder on the left side. The left lung is trilobed and the right lung bilobed, and blood vessels, nerves, lymphatics and the intestines are also transposed.
If the heart is swapped to the right side of the thorax, it is known as situs inversus with dextrocardia or situs inversus totalis. If the heart remains in the normal left side of the thorax, a much rarer condition (1 in 22,000 of the general population), it is known as situs inversus with levocardia or situs inversus incompletus. Situs inversus with levocardia, or dextrocardia without situs inversus, present much higher rates of congenital defects than situs inversus with dextrocardia.
Significance
Situs inversus is generally an autosomal recessive genetic condition, although it can be X-linked or found in identical "mirror" twins.[2]
In the absence of congenital heart defects, individuals with situs inversus are phenotypically unimpaired, and can lead normal healthy lives, without any complications related to their medical condition. There is a 5–10% prevalence of congenital heart disease in individuals with situs inversus totalis, most commonly transposition of the great vessels. The incidence of congenital heart disease is 95% in situs inversus with levocardia.
Many people with situs inversus totalis are unaware of their unusual anatomy until they seek medical attention for an unrelated condition. The reversal of the organs may then lead to some confusion, as many signs and symptoms will be on the 'wrong' side. For example, if an individual with situs inversus develops appendicitis, they will present to the physician with lower left abdominal pain, since that is where their appendix lies. Thus, in the event of a medical problem, the knowledge that the individual has situs inversus can expedite diagnosis. People with this rare condition may inform their physicians before an examination, so the physician can redirect their search for heart sounds and other signs. Wearing a medical identification tag can help to inform health care providers in the event the person is unable to communicate.
Situs inversus also complicates organ transplantation operations as donor organs will almost certainly come from situs solitus (normal) donors. As hearts and livers are chiral, geometric problems arise placing an organ into a cavity shaped in the mirror image. For example, a person with situs inversus who requires a heart transplant needs all the vessels to the transplant donor heart reattached to their existing ones. However, the orientation of these vessels in a person with situs inversus is reversed, necessitating steps so that the blood vessels join properly.
Kartagener syndrome
About 25% of individuals with situs inversus have an underlying condition known as primary ciliary dyskinesia (PCD). PCD is a dysfunction of the cilia that manifests itself during the embryologic phase of development. Normally-functioning cilia determine the position of the internal organs during early embryological development, and so individuals with situs inversus have a 50% chance of developing PCD. If they do, they are said to have Kartagener syndrome, characterized by the triad of situs inversus, chronic sinusitis, and bronchiectasis. Cilia are also responsible for clearing mucus from the lung, and the dysfunction causes increased susceptibility to lung infections.
Notable persons with situs inversus
Notable individuals with documented cases of situs inversus include:
- Randy Foye, an American basketball player in the NBA. He has suffered no discernible complications, and the condition is not expected to jeopardize his career as a professional athlete.[3]
- Catherine O'Hara, the Canadian comedic actress has said in interviews that her organs are reversed and her heart is on the right side of her chest.[4]
Fictional characters with situs inversus
- In the Ian Fleming novel Dr. No, Julius No explains to James Bond that he once survived a murder attempt because his heart is located on his right side, which his would-be-killers did not know when they stabbed the spot on the left where the heart of a normal human being would be.
- Souther, from the anime/manga Fist of the North Star, has situs inversus totalis, making him immune to standard pressure-points martial arts.
- In the WB series Jack & Jill, Simon Rex played a young man with situs inversus.
- Fortune, from Metal Gear Solid 2: Sons of Liberty. Revolver Ocelot points this out when he shoots Fortune on the left side of her chest, then remembers and states that her heart was on the right side.
- In an ER Series entitled "Freak Show", Romano, Benton and Corday operate on a unique case involving a boy with reversed organs.
- In Margaret Mahy's novel The Tricksters, the character Hadfield is said to be an exact mirror image of his otherwise identical twin Felix, including having his vital organs in mirror-image layout.
- In the Lord Peter Wimsey short story The Image in the Mirror by Dorothy Sayers, a character with reversed organs has long been haunted by dreams of a doppelgänger and by fears that he himself might be only the reflection of someone else.
- In the Max Brooks novel World War Z, a character describes operating on a patient who had dextrocardia with situs inversus, and transplants a heart from someone with the same condition. Unbeknownst to him, the transplant heart is infected with the virus Solanum, thus turning the patient into a zombie.
- In the science fiction novel Doorways in the Sand by Roger Zelazny the character Fred Cassidy goes through a device that completely reverses the left-right symmetry of his entire body (even to the point where he perceives writing and other images as their mirror image). The fact that his heart is on the wrong side ends up saving him from being killed by a bullet wound.
- In the science fiction short story Technical Error by Arthur C. Clarke, a man is inverted extradimensionally in a strong magnetic field due to an industrial accident. Doctors find he is unable to digest food due to the nutrient molecules being incompatible with his reversed enzymes and receptors. Efforts to re-invert him prove catastrophic.
- In Luck (film) Hindi movie(2009), the character 'Ram' has heart on right side instead of left which saves him in the end.
See also
- Situs solitus
- Situs ambiguus
- Ectopia cordis
- Asplenia
- Polysplenia
- Chirality (mathematics)
- Johann Friedrich Meckel, the Elder
References
- ^ Situs inversus on eMedicine
- ^ [Gedda L, Sciacca A, Brenci G, Villatico S, Bonanni G, Gueli N, Talone C. Situs viscerum specularis in monozygotic twins. Acta Genet Med Gemellol (Roma) 1984; 33(1): 81-5.]
- ^ http://wcco.com/sports/Minnesota.Timberwolves.Randy.2.371610.html Rookie T-Wolf's Organs Reversed
- ^ http://www.cbc.ca/thehour/video.php?id=2048 The Hour - 2 Minutes: Catherine O'Hara
- McManus, Chris (2002). Right Hand, Left Hand. Harvard University Press. ISBN 0-674-00953-3. this book was the 2003 Aventis winner and has a description of the history behind the discovery of this medical condition.
- Yokoyama T, Copeland NG, Jenkins NA, Montgomery CA, Elder FF, Overbeek PA (1993). "Reversal of left-right asymmetry: a situs inversus mutation". Science. 260 (5108): 679–682. doi:10.1126/science.8480178. PMID 8480178.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Lowe LA, Supp DM, Sampath K; et al. (1996). "Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus". Nature. 381 (6578): 158–161. doi:10.1038/381158a0. PMID 8610013.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Levin M (1997). "Left-right asymmetry in vertebrate embryogenesis". Bioessays. 19 (4): 287–296. doi:10.1002/bies.950190406. PMID 9136626.
- Levin M, Pagan S, Roberts DJ, Cooke J, Kuehn MR, Tabin CJ (1997). "Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo". Dev. Biol. 189 (1): 57–67. doi:10.1006/dbio.1997.8662. PMID 9281337.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Logan M, Pagán-Westphal SM, Smith DM, Paganessi L, Tabin CJ (1998). "The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals". Cell. 94 (3): 307–317. doi:10.1016/S0092-8674(00)81474-9. PMID 9708733.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Stern CD, Wolpert L (2002). "Left-right asymmetry: all hands to the pump". Curr. Biol. 12 (23): R802–803. doi:10.1016/S0960-9822(02)01312-X. PMID 12477404.