Squalene methyltransferase
| Squalene methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.262 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Squalene methyltransferase (EC 2.1.1.262, TMT-1, TMT-2) is an enzyme with systematic name S-adenosyl-L-methionine:squalene C-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + squalene 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene (overall reaction)
- (1a) S-adenosyl-L-methionine + squalene S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene
- (1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
There are two isoforms in the green alga Botryococcus braunii BOT22 that differ in their specificity .
References
- ^ Niehaus, T.D.; Kinison, S.; Okada, S.; Yeo, Y.S.; Bell, S.A.; Cui, P.; Devarenne, T.P.; Chappell, J. (2012). "Functional identification of triterpene methyltransferases from Botryococcus braunii race B". J. Biol. Chem. 287: 8163–8173. doi:10.1074/jbc.m111.316059. PMID 22241476.
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External links
- Squalene+methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)