Sulfinoalanine decarboxylase

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Sulfinoalanine decarboxylase
Cysteine sulfinic acid decarboxylase homodimer, Human
EC no.
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a sulfinoalanine decarboxylase (EC is an enzyme that catalyzes the chemical reaction

3-sulfino-L-alanine hypotaurine + CO2

Hence, this enzyme has one substrate, 3-sulfino-L-alanine (also known as Cysteine sulfinic acid), and two products, hypotaurine and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming). Other names in common use include cysteine-sulfinate decarboxylase, L-cysteinesulfinic acid decarboxylase, cysteine-sulfinate decarboxylase, CADCase/CSADCase, CSAD, cysteic decarboxylase, cysteinesulfinic acid decarboxylase, cysteinesulfinate decarboxylase, sulfoalanine decarboxylase, and 3-sulfino-L-alanine carboxy-lyase. This enzyme participates in taurine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JIS.


  • Guion-Rain MC, Portemer C, Chatagner F (1975). "Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties". Biochim. Biophys. Acta. 384 (1): 265–76. doi:10.1016/0005-2744(75)90115-1. PMID 236774.
  • JACOBSEN JG, THOMAS LL, SMITH LH (1964). "Properties and Distribution of Mammalian L-Cysteine Sulfinate Carboxy-Lyases". Biochim. Biophys. Acta. 85: 103–16. doi:10.1016/0926-6569(64)90171-3. PMID 14159288.