Sulfinoalanine decarboxylase

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sulfinoalanine decarboxylase
Identifiers
EC number 4.1.1.29
CAS number 62213-10-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a sulfinoalanine decarboxylase (EC 4.1.1.29) is an enzyme that catalyzes the chemical reaction

3-sulfino-L-alanine hypotaurine + CO2

Hence, this enzyme has one substrate, 3-sulfino-L-alanine, and two products, hypotaurine and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming). Other names in common use include cysteine-sulfinate decarboxylase, L-cysteinesulfinic acid decarboxylase, cysteine-sulfinate decarboxylase, CADCase/CSADCase, CSAD, cysteic decarboxylase, cysteinesulfinic acid decarboxylase, cysteinesulfinate decarboxylase, sulfoalanine decarboxylase, and 3-sulfino-L-alanine carboxy-lyase. This enzyme participates in taurine and hypotaurine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JIS.

References[edit]

  • Guion-Rain MC, Portemer C, Chatagner F (1975). "Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties". Biochim. Biophys. Acta. 384 (1): 265–76. PMID 236774. doi:10.1016/0005-2744(75)90115-1. 
  • JACOBSEN JG, THOMAS LL, SMITH LH (1964). "PROPERTIES AND DISTRIBUTION OF MAMMALIAN L-CYSTEINE SULFINATE CARBOXY-LYASES". Biochim. Biophys. Acta. 85: 103–16. PMID 14159288. doi:10.1016/0926-6569(64)90171-3.