TRIM27

TRIM27
Identifiers
Aliases	TRIM27, RFP, RNF76, tripartite motif containing 27
External IDs	OMIM: 602165; MGI: 97904; HomoloGene: 111010; GeneCards: TRIM27; OMA:TRIM27 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	28,923,988 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	21,378,894 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; right lobe of liver; ; endometrium; ; canal of the cervix; ; blood; ; spleen; ; pituitary gland; ; anterior pituitary; ; granulocyte;
	Top expressed in
	internal carotid artery; ; Paneth cell; ; external carotid artery; ; condyle; ; fossa; ; primary oocyte; ; Rostral migratory stream; ; spermatid; ; primitive streak; ; lacrimal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; nucleic acid binding; transmembrane receptor protein tyrosine kinase activity; identical protein binding; transferase activity; ubiquitin protein ligase activity; SUMO transferase activity;
Cellular component	cytoplasm; endosome; PML body; nuclear membrane; membrane; integral component of plasma membrane; intracellular anatomical structure; nucleoplasm; retromer complex; early endosome; nucleus; fibrillar center; nucleolus; cytosol;
Biological process	regulation of transcription, DNA-templated; negative regulation of adaptive immune response; negative regulation of protein kinase activity; protein K63-linked ubiquitination; protein trimerization; positive regulation of DNA-binding transcription factor activity; transcription, DNA-templated; negative regulation of calcium ion import; negative regulation of gene expression, epigenetic; retrograde transport, endosome to Golgi; spermatogenesis; Arp2/3 complex-mediated actin nucleation; negative regulation of tumor necrosis factor production; cell population proliferation; peptidyl-tyrosine phosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of viral transcription; innate immune response; positive regulation of actin nucleation; protein sumoylation;
	Sources:Amigo / QuickGO
Orthologs
	5987
	19720
ENSG00000229006; ENSG00000233948; ENSG00000204713; ENSG00000215641; ENSG00000237071;
	ENSG00000237462; ENSG00000234495
	ENSMUSG00000021326
	P14373
	Q62158
	NM_030950; NM_006510
	NM_009054
	NP_006501
	NP_033080
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.^[5]^[6]

Template:PBB Summary

Interactions

TRIM27 has been shown to interact with PRAM1^[7] and EIF3S6.^[8]

References

^ ^a ^b ^c ENSG00000233948, ENSG00000204713, ENSG00000215641, ENSG00000237071, ENSG00000237462, ENSG00000234495 GRCh38: Ensembl release 89: ENSG00000229006, ENSG00000233948, ENSG00000204713, ENSG00000215641, ENSG00000237071, ENSG00000237462, ENSG00000234495 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021326 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vernet C, Boretto J, Mattei MG, Takahashi M, Jack LJ, Mather IH, Rouquier S, Pontarotti P (Mar 1994). "Evolutionary study of multigenic families mapping close to the human MHC class I region". J Mol Evol. 37 (6): 600–12. Bibcode:1993JMolE..37..600V. doi:10.1007/bf00182746. PMID 8114113.
^ "Entrez Gene: TRIM27 tripartite motif-containing 27".
^ Cao, T; Duprez E; Borden K L; Freemont P S; Etkin L D (May 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10). ENGLAND: 1319–29. ISSN 0021-9533. PMID 9570750. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Morris-Desbois, C; Bochard V; Reynaud C; Jalinot P (Oct 1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies". J. Cell Sci. 112 (19). ENGLAND: 3331–42. ISSN 0021-9533. PMID 10504338. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading