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TRNA1Val (adenine37-N6)-methyltransferase

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TRNA1Val (adenine37-N6)-methyltransferase
Identifiers
EC no.2.1.1.223
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

TRNA1Val (adenine37-N6)-methyltransferase (EC 2.1.1.223, YfiC) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA1Val (adenine37-N6)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine37 in tRNA1Val S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1Val

The enzyme specifically methylates adenine37 in tRNA1Val (anticodon cmo5UAC).

References

  1. ^ Golovina, A.Y.; Sergiev, P.V.; Golovin, A.V.; Serebryakova, M.V.; Demina, I.; Govorun, V.M.; Dontsova, O.A. (2009). "The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC)". RNA. 15: 1134–1141. doi:10.1261/rna.1494409. PMID 19383770.