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TRNA (cytidine32/uridine32-2'-O)-methyltransferase

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TRNA (cytidine32/uridine32-2'-O)-methyltransferase
Identifiers
EC no.2.1.1.200
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TRNA (cytidine32/uridine32-2'-O)-methyltransferase (EC 2.1.1.200, YfhQ, tRNA:Cm32/Um32 methyltransferase, TrMet(Xm32), TrmJ) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/uridine32-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + cytidine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA
(2) S-adenosyl-L-methionine + uridine32 in tRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine32 in tRNA

In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA.

References

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  1. ^ Purta E, van Vliet F, Tkaczuk KL, Dunin-Horkawicz S, Mori H, Droogmans L, Bujnicki JM (July 2006). "The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase". BMC Molecular Biology. 7: 23. doi:10.1186/1471-2199-7-23. PMC 1569432. PMID 16848900.
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