TRNA (guanine37-N1)-methyltransferase
| TRNA (guanine37-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.228 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA (guanine37-N1)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine37-N1)-methyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine37 in tRNA S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
This enzyme is important for the maintenance of the correct reading frame during translation.
References
- ^ Takeda, H.; Toyooka, T.; Ikeuchi, Y.; Yokobori, S.; Okadome, K.; Takano, F.; Oshima, T.; Suzuki, T.; Endo, Y.; Hori, H. (2006). "The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus". Genes Cells. 11: 1353–1365. doi:10.1111/j.1365-2443.2006.01022.x. PMID 17121543.
- ^ Lee, C.; Kramer, G.; Graham, D.E.; Appling, D.R. (2007). "Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase". J. Biol. Chem. 282: 27744–27753. doi:10.1074/jbc.m704572200. PMID 17652090.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ O'Dwyer, K.; Watts, J.M.; Biswas, S.; Ambrad, J.; Barber, M.; Brule, H.; Petit, C.; Holmes, D.J.; Zalacain, M.; Holmes, W.M. (2004). "Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth". J. Bacteriol. 186: 2346–2354. doi:10.1128/jb.186.8.2346-2354.2004. PMID 15060037.
- ^ Brule, H.; Elliott, M.; Redlak, M.; Zehner, Z.E.; Holmes, W.M. (2004). "Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein". Biochemistry. 43: 9243–9255. doi:10.1021/bi049671q. PMID 15248782.
- ^ Goto-Ito, S.; Ito, T.; Ishii, R.; Muto, Y.; Bessho, Y.; Yokoyama, S. (2008). "Crystal structure of archaeal RNA(m1G37)methyltransferase aTrm5". Proteins. 72: 1274–1289. doi:10.1002/prot.22019. PMID 18384044.
- ^ Ahn, H.J.; Kim, H.W.; Yoon, H.J.; Lee, B.I.; Suh, S.W.; Yang, J.K. (2003). "Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition". EMBO J. 22: 2593–2603. doi:10.1093/emboj/cdg269. PMID 12773376.
External links
- TRNA+(guanine37-N1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)