Talk:Ball and chain inactivation

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Molecular Biology: MCB

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I am a final year undergraduate Biology student and I have created this page as part of my coursework for a Science Communication module. Clara fcn (talk) 20:10, 25 March 2015 (UTC)[reply]

Muddled

the article is confusing because it conflates the original "ball and chain" idea with the "hinged lid" idea. The original squid work of Armstrong had 2 separate components, the removal of the inactivation of Na channels by pronase, and the analysis of open-channel block (by TEA derivatives) of noninactivatng K channels. Combining and extrapolating these 2 results Armstrong suggested the b&c idea. Subsequent work with inactivating shaker channels suggested an N-terminal ball competed with alkyl tea for the inner vestibule. Molecular work by Caterall then suggested a variant of the b&c idea for Na channels, the lid and chain between domains 3 and 4. The article doesn't really separate and clearly describe these ideas and their evolution. see Armstrong article DOI: 10.1085/jgp.201711835 Paulhummerman (talk) 20:26, 2 December 2019 (UTC)[reply]