Talk:Central nervous system fatigue

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/Georgia Tech Intro to Neuroscience

reliance on primary sources

Hi - please read WP:MEDRS. This article has a lot of sourcing problems. I'm sorry if your instructor didn't go over our medical sourcing standards, but Wikipedia doesn't allow the use of primary sources etc in articles about medicine. I'm going to drop some cleanup tags on the page until the sourcing problems are addressed. Thanks, Kevin Gorman (talk) 00:33, 19 November 2013 (UTC)[reply]

Review of Nicotine/Caffeine's effect

To add^[1] Seppi333 (Insert 2¢) 05:55, 13 March 2016 (UTC)[reply]

References

^ Pesta DH, Angadi SS, Burtscher M, Roberts CK (2013). "The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance". Nutr Metab (Lond). 10 (1): 71. doi:10.1186/1743-7075-10-71. PMC 3878772. PMID 24330705. In summary, caffeine, even at physiological doses (3–6 mg/kg), as well as coffee are proven ergogenic aids and as such – in most exercise situations, especially in endurance-type events – clearly work-enhancing [26]. It most likely has a peripheral effect targeting skeletal muscle metabolism as well as a central effect targeting the brain to enhance performance, especially during endurance events (see Table 1). Also for anaerobic tasks, the effect of caffeine on the CNS might be most relevant. ... Muendel et al. [93] found a 17% improvement in time to exhaustion after nicotine patch application compared to a placebo without affecting cardiovascular and respiratory parameters or substrate metabolism. In this sense, nicotine seems to exert similar effects as caffeine by delaying the development of central fatigue as impaired central drive is an important factor contributing to fatigue during exercise. ... Co-ingestion of caffeine and nicotine exhibit additive effects on cardiovascular parameters such as blood pressure during baseline conditions but less than additive effects during conditions of physical and mental stress and sympathoadrenal stimulation [172]. ... The physiological effects of the above mentioned substances are well established. However, the ergogenic effect of some of the discussed drugs may be questioned and one has to consider the cohort tested for every specific substance. However, only caffeine has enough strength of evidence to be considered an ergogenic aid.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Noakes / psychological aspects

The article talks a lot about neurotransmitters and stimulants, but fails to mention the psychological aspects which appear to be some of the most important factors in determining central fatigue. These are discussed in the Noakes 2012 review which we already have in the article. In fact, it would probably be worth expanding the article based on the Noakes review, as they give a very good review of the history behind the science of fatigue, as well as our current understanding. --sciencewatcher (talk) 17:28, 21 March 2016 (UTC)[reply]

TBI

Central fatigue is a major symptom of chronic harm after Traumatic Brain Injury. It needs coverage in this article. — Lentower (talk) 19:39, 21 February 2019 (UTC)[reply]

This term not medical mainstream?

No used by mainstream medical sources. No recent follow-through e.g. https://www.google.com/search?q=Central+nervous+system+fatigue&rlz=1C9BKJA_enGB1034GB1035&hl=en-GB&sourceid=chrome-mobile&ie=UTF-8 JCJC777 (talk) 20:27, 2 January 2023 (UTC)[reply]

[pmid24330705-1] Pesta DH, Angadi SS, Burtscher M, Roberts CK (2013). "The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance". Nutr Metab (Lond). 10 (1): 71. doi:10.1186/1743-7075-10-71. PMC 3878772. PMID 24330705. In summary, caffeine, even at physiological doses (3–6 mg/kg), as well as coffee are proven ergogenic aids and as such – in most exercise situations, especially in endurance-type events – clearly work-enhancing [26]. It most likely has a peripheral effect targeting skeletal muscle metabolism as well as a central effect targeting the brain to enhance performance, especially during endurance events (see Table 1). Also for anaerobic tasks, the effect of caffeine on the CNS might be most relevant. ... Muendel et al. [93] found a 17% improvement in time to exhaustion after nicotine patch application compared to a placebo without affecting cardiovascular and respiratory parameters or substrate metabolism. In this sense, nicotine seems to exert similar effects as caffeine by delaying the development of central fatigue as impaired central drive is an important factor contributing to fatigue during exercise. ... Co-ingestion of caffeine and nicotine exhibit additive effects on cardiovascular parameters such as blood pressure during baseline conditions but less than additive effects during conditions of physical and mental stress and sympathoadrenal stimulation [172]. ... The physiological effects of the above mentioned substances are well established. However, the ergogenic effect of some of the discussed drugs may be questioned and one has to consider the cohort tested for every specific substance. However, only caffeine has enough strength of evidence to be considered an ergogenic aid.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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