Talk:Flumazenil

Pharmacology Mid‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Chemicals Low‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Low	This article has been rated as Low-importance on the project's importance scale.

Medicine Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Flumazenil.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Anxiety

This stuff probably causes brutal anxiety in many people. Benzo withdrawal itself causes nightmarish anxiety, with episodes of panic, which can persist for months. I suspect Flumazenil would make it worse in many cases. A benzo-induced coma is not a good thing, certainly. Waking up from a coma into an all-out panic attack would be really bad, and would present patient management problems of its own.

Years ago, I read of some kind of benzo antagonist being used by Soviet authorities on political dissidents, in psychiatric hospitals, as a torture method. Ugly.

There's plenty of medical evidence for this problem. Just google "Flumazenil (anxiety OR panic)" without the quotes.

This article should mention some of these issues. 69.110.107.45 (talk) 00:50, 11 October 2013 (UTC)[reply]

A benzo antagonist like flumazenil has no effect on healthy individuals because no chemicals in the body naturally bind to the benzodiazepine site. 94.195.135.88 (talk) 06:50, 31 August 2016 (UTC)[reply]

I find it interesting that we call this drug an antagonist of the benzodiazepine receptor, and yet we do not get withdrawal symptoms when it is administered to dependent patients. I suspect this drug is actually an extremely "close to normal function" partial agonist? Can someone clarify this for me please? — Preceding unsigned comment added by 121.44.197.228 (talk) 23:20, 14 June 2019 (UTC)[reply]

Silent Allosteric Modulator

This page states (in the introduction) that Flumazenil is an antagonist of the GABAa receptor. This is technically incorrect. An antagonist of the GABAa receptor would prevent GABA from activating the receptor, while Flumazenil has no effect on GABA binding or activity.

I think the most accurate classification for Flumazenil is a silent allosteric modulator of the GABAa receptor, as it only affects the binding of compounds to the BZD site without affecting activity otherwise. — Preceding unsigned comment added by 141.214.17.201 (talk) 20:57, 13 October 2013 (UTC)[reply]

IUPAC Name

Hey, shouldn't the IUPAC name be Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate? --PolynomialHelix (talk) 02:42, 4 November 2014 (UTC)[reply]

There should be a link to the "Downregulation and upregulation"

The article would be better understood if the reader was provided a link that explains what up and down regulation mean. — Preceding unsigned comment added by 172.78.76.206 (talk) 02:42, 27 April 2016 (UTC)[reply]

External links modified

Hello fellow Wikipedians,

I have just modified one external link on Flumazenil. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

Added archive https://web.archive.org/web/20080625161218/http://www.rocheusa.com/products/romazicon/pi.pdf to http://www.rocheusa.com/products/romazicon/pi.pdf

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 21:37, 8 September 2017 (UTC)[reply]

Possible sneaky vandalism

Hi!

I suspect that this edit might be a sneaky bit of vandalism. What are your thoughts? Is otic flumazenil administration really a thing?

Regards, TealHill (talk) 07:28, 21 July 2020 (UTC)[reply]