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WikiProject Medicine / Pathology (Rated C-class, High-importance)
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Links to cryonics are too obscure to belong in a very general article on ischemia. Links to organ preservation for transplantation purposes are more in touch with the subject than this. Also avoid dumping external links everywhere that only emphasise fringe statements. JFW | T@lk 08:47, 16 May 2004

Hypoxia vs. Ischaemia[edit]

For a reduction in oxygen the term "hypoxia" is more often used and more accurate. Ischemia should be reserved for a reduction in blood supply. content of article:

* inability of the tissues to extract oxygen from the blood (e.g. sepsis)

There is no inability of tissue to extract oxygen, the ability of the tissue to "use" oxygen is dependent of vital cells ! Sepsis is a far more complicate life threatening syndrome than an "unability of extracting oxygen" or whatever the editor meant.

If insufficient oxygen is supplied to the tissue to maintain life in that tissue, the tissue dies, or infarcts.

answer: Tissue never dies, it is the human being or animals that die but not tissues. Tissues can become hypoxic, anoxic, apoptotic or necrotic. User:

You can make these changes yourself, just press "edit" at the bottom! I have made some changes on the basis of your suggestions. JFW | T@lk 19:49, 16 Jun 2004 (UTC)

Ischemic Cascade[edit]

I know the ischemic cascade occurs in brain tissue, and I'm pretty sure something like it occurs in other tissues, eg the heart. but I'm not sure how the processes differ or if they are also called ischemic cascade since I only know about the case for the brain. If you have evidence of the same or similar processes occurring in other tissues, please add that. It would also be good if you could edit the ischemic cascade page that I am about to create. --Delldot 20:27, 8 October 2005 (UTC)

Not an expert, but I know that all animal cells rely on oxygen to convert ADP to ATP, the intracellular energy mollecuole, to maintain cell membranes. All cells must expend energy to actively maintain both internal membranes of macuoles, mitochondria, and other organelles as well as the external cell membrane. Muscle cells and especially nerve cells are more sensitive to imbalance of calcium ions because their cell membranes are adapted to electrical excitability (polarization) by opening ion gates in te membrane, allowing ions to pass through channels in the membranes, then actively pump ions back out to restore the previous polarity. Without oxygen to make ATP to fuel this process, nerve and muscle cells quickly acquire calcium ion imbalances. Other tissues will also experience desgradation of membranes at a slower rate. These slower membrane degredations cause leakage of enzymes, damage to organelles, and escalation of the ischemic cascade. Stephen Charles Thompson (talk) 08:40, 1 February 2012 (UTC)


There is another form of Ischemic's called Ischemia Heart Disease...not enough blood to the heart...causes chest pain, neck or jaw pain, arm pain, clammy pain, shortness of breath, Nausea, and or vomiting...treatment is as follows:::medication, exercise, angiopalsty, and bypass is a life-threatening can cause abnormal heart rythem(arrhythmia0, which can lead to fainting or even sudden death... That's all I know... IIDoomII

Well, I'm glad that you chose this talkpage to share your knowledge. JFW | T@lk 01:35, 14 October 2005 (UTC)

ischemic retinal vein occlusion[edit]

I'm no MD, to be sure. Yet when I was recently diagnosed with "Ischemic branch retinal vein occlusion" it was explained to me in this way.

On occasion the arterioles supplying blood to the eye (two branch incoming and one central outgoing) will collapse. This is usually a result of cardiovascular disease. When an arteriole collapses the blood flow to the eye--particularly the macular area--is disrupted. The result is loss of vision, partial or complete, usually permanent. (Nerve cells don't typically grow back in these situations.

Anyway, would someone who knows something about this add a reference to it somewhere on the page? Apparently it is one of the top two causes of loss of vision.

Vagabundus 08:16, 1 June 2007 (UTC)

There is also Raynaud's Phenomenon[edit]

There the ischaemia is trigged by vasospasm. JoshNarins (talk) 14:29, 2 October 2010 (UTC)

Therapeutic uses of Ischemic Compression[edit]

I think that this article should include a section on the intentional use of Ischemia as it applies to Physical Therapy. Alternatively, one could simply include a link to the associated Wikipedia page. Any objections before I include it? (talk) 12:43, 8 March 2012 (UTC)

I'm ignorant of the subject but I hope you plan on adding reliable medical sources (WP:MEDRS) along with this new content. Biosthmors (talk) 17:47, 8 March 2012 (UTC)


Shouldn't the sentence: "Anemia vasoconstricts the periphery so that red blood cells can work internally on vital organs such as the heart, brain, etc., thus causing lack of oxygen to the periphery."

contain a "can't" instead of "can"? — Preceding unsigned comment added by (talk) 10:46, 14 January 2013 (UTC)

Proposed merge[edit]

I have proposed a merge between Acute arterial ischemic disorder and this article because:

  • These appear to be about the same topic

Kind regards, LT90001 (talk) 07:47, 23 September 2013 (UTC)

It has also been proposed that the article Renal ischemia be merged into the article Ischemia. I am against that merge. Renal ischemia is a potential topic in and of itself. The article “Renal ischemia” should be expanded and improved.--Solomonfromfinland (talk) 20:09, 18 December 2014 (UTC)

I am a retired MD. In trying to look up spontaneous renal infarct, I found little. I agree with Solomon that the subject of renal infarction, renal ischemia, etc should be kept separate and experts on this subject should be heard. David R. Youberg MD, — Preceding unsigned comment added by (talk) 13:42, 10 December 2015 (UTC)