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Side effects[edit]

Most recent edit added side effects taken from the medication factsheet that came with the prednisolone I've just been prescribed. 20:04, 2 September 2007 (UTC)

Banned substance[edit]

Can anyone shed some light on why prednisolone is a banned substance for athletes? Anabolic steroids I obviously understand, but how would prednisolone enhance performance? (talk) 19:48, 25 January 2008 (UTC)

by inhibiting the inflammatory reponse in overtaxed joints and muscles. pitchers' arms, polevaulters' shoulders, everybody's knees. its like a super ice pack. why is it banned? just look at that list of adverse side effects. moreover, pain is nature's way of saying 'don't do that any more'. inhibit the pain response and you can do serious damage to musculoskelatal anatomy over time. not saying that any of them abused corticosteroids, but look at all the ex-jocks walking around on 2 artificial knees. that's what you get from 'playing with pain'.Toyokuni3 (talk) 04:20, 25 August 2008 (UTC)

Prednisolone won't be tasted[edit]

Since prednisolone is the active metabolite of prednisone and is only formed at the liver then isn't it prednisone that has the bitter taste "that makes it difficult to administer to children"? The line concerned should be removed from this article and transferred to the prednisone article. Meltyman (talk) 08:14, 17 May 2008 (UTC)

Additional ADRs of Corticosteroids[edit]

A recently obtained (7/26/2011) drug information sheet from a local branch of a nationwide pharmacy lists under cautions:

"Corticosteroid medicines may affect growth rate in children and adolescents in some instances." One presumes this is a long course.

Consultation with a doctor before being immunized while on a course of Prednisolone.

Is excreted in breast milk.

Advises physician consultation for use during pregnancy. (talk) 02:29, 27 July 2011 (UTC)Literate Dad (talk) 09:42, 25 October 2012 (UTC)

Contaminated Lots of Methylprednisolone Acetate[edit]

Infections under Investigation [1]in Patients Exposed to NECC[2]Products Other than the 3 Contaminated Lots of Methylprednisolone Acetate

Meningitis, Spinal or Paraspinal Infection A person who developed any of the following after epidural or paraspinal2 injection after May 21, 2012 of an NECC product:

Meningitis of unknown etiology. Osteomyelitis, abscess or other infection (e.g., soft tissue infection) of unknown etiology, in the spinal or paraspinal structures at or near the site of injection. Fungal Infection of Interest A person who developed fungal infection in a normally sterile site4 with laboratory evidence by culture, histopathology, molecular (e.g. NAAT or PCR), or positive galactomannan test following administration of an NECC product into a sterile site after May 21, 2012.

1.Products from NECC other than the 3 contaminated lots (05212012@68, 06292012@26, 08102012@51) of methylprednisolone acetate.

2.Paraspinal injections include, but are not limited to, spinal facet joint injection, sacroiliac joint injection,or spinal or paraspinal nerve root/ganglion block.

3.Clinically diagnosed meningitis with one or more of the following symptoms: headache, fever, stiff neck, or photophobia, in addition to a CSF profile showing pleocytosis (>5 white blood cells, adjusting for presence of red blood cells by subtracting 1 white blood cell for every 500 red blood cells present) regardless of glucose or protein levels.

4.Normally sterile sites include blood, CSF, pleural fluid, peritoneal fluid, pericardial fluid, surgical aspirate, bone, joint fluid, or internal body site (e.g., eye, lymph node or brain).

[3] [4] Division of Healthcare Quality Promotion (DHQP) (talk) 08:22, 25 October 2012 (UTC) (talk) 09:15, 25 October 2012 (UTC) (talk) 09:34, 25 October 2012 (UTC) (talk) 09:36, 25 October 2012 (UTC) (talk) 09:42, 25 October 2012 (UTC)

Edits by Pharming 16[edit]

We edited the content explaining the mechanism of action for prednisolone. There was no reliable way of cross checking the outdated references so we used more recent data from a secondary source to explain this section. We also updated the potential side effects that may occur with Prednisolone. In addition, we found review articles to support some statements made what prednisolone may be used for. — Preceding unsigned comment added by Pharming16 (talkcontribs) 19:25, 5 November 2015 (UTC)

Peer Review from Gyang15[edit]

The article does contain a neutral view. The cited references are verifiable. Our recommendations include: Pros: Good, clear explanation of the mechanism of action for prednisolone. There are high quality references for mechanism of action. Cons:

The lead should include other general information about prednisolone, such as it’s most common/major indications and common side effects. It wouldn’t hurt to put references for all of the adverse effects or to reference that a certain source covers all of the adverse effects. I can’t seem to find a source for your image in the MOA section. The paper you used for the text is great, but it’s hard to be certain the image reflects that. — Preceding unsigned comment added by Gyang15 (talkcontribs) 02:59, 9 November 2015 (UTC)