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I suggest reviewing the sentence "the abnormally folded shape has very little free energy (...)" in the Mad-cow disease section. Maybe the author meant very low free energy? A reference is also missing in this section. — Preceding unsigned comment added by 188.8.131.52 (talk) 19:46, 30 December 2011 (UTC)
This article needs serious revision, preferably by an expert in the field of protein engineering. At the moment, this article is complete conjecture because no citations were found. Overall, the article will probably need to be rewritten.
Last edited at 04:20, 29 March 2007 (UTC). Substituted at 03:28, 30 April 2016 (UTC)