Talk:Substance P

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Citations linking to privateor unaccessable articles[edit]

[[a b Harrison S, Geppetti P (June 2001). "Substance p". The International Journal of Biochemistry & Cell Biology 33 (6): 555–76. doi:10.1016/S1357-2725(01)00031-0. PMID 11378438.]]

It's not available to everyone therefore shouldn't be used as a link. How can I verify it if I can't access it? Has anyone got a link to a free article that shows the same conclusion Harrison S, Geppetti P (June 2001)? —Preceding unsigned comment added by (talk) 16:31, 8 October 2010 (UTC)

Reference needed[edit]

"Naked Mole Rats lack Substance P and do not feel pain when painful stimuli are administered to the skin." This is a bold statement that needs to be backed up with reference(s). Tootallterri 23:24, 14 August 2007 (UTC)

Done. Welcome to Wikipedia, by the way! Fvasconcellos (t·c) 00:12, 15 August 2007 (UTC)

Relation to Depression[edit]

Should perhaps be mentioned —Preceding unsigned comment added by (talk) 05:34, 19 April 2011 (UTC)

Chembox template not displaying correctly in Mozilla Firefox[edit]

For some reason this chembox is spashed all across the screen using Firefox 8.0 but looks perfectly normal using IE 8. Looking at the obvious things in the code, like the number of open and closed brackets, nothing immediately jumps out at me as causing the problem. (I'm on a public computer where I can't log on, but I'm User:Trilobitealive). (talk) 22:21, 11 November 2011 (UTC)

For debugging purposes the problem appears to arise with: Revision as of 12:22, 7 November 2010 by Beetstra. Will look deeper when I can get to a computer where I can log on. 22:39, 11 November 2011 (UTC) (talk) 22:39, 11 November 2011 (UTC)
It seems that this is caused by the InChI template in the chembox identifiers. The data under it is so long that it expands the box itself. Apparently Firefox renders the template before calculating it needs to resize it, causing the size jump. I got no idea how to fix this though - all the testcases i found are shorter strings of data. Excirial (Contact me,Contribs) 22:55, 11 November 2011 (UTC)
I'm not going to mess up the data but I wonder what would happen if one put extra spaces about every 40 characters?Trilobitealive (talk) 00:56, 12 November 2011 (UTC)

reference 26/Brown, M and Vale,W 2011, or is it 1976[edit]

Reference 26 "Brown, M and Vale,W - EFFECTS OF NEUROTENSIN AND SUBSTANCE P ON PLASMA INSULIN, GLUCAGON AND GLUCOSE LEVELS. (2011)." goes to a link to an that's " Copyright © 1976 by The Endocrine Society" Should the date be corrected? 2011 seems a little misleading/not verifiable by that link . Also could any with access to the text of the Brown and Vale reference verify how substance P was administrated for that reference. There's often a fair difference in the effects of substances due to the route/location of administration. It could be very misleading to imply the effects are different in different animals when other "variables" weren't well controlled. (talk) 21:40, 26 November 2011 (UTC)


The text says "Capsaicin is clinically used as an analgesic and an inflammatory agent to reduce pain associated with arthritis and many types of neuralgia." Is it an inflammatory agent or an anti-inflammatoy agent? If SP is inflammatory and capsaicin reduces SP, capsaicin should be anti-inflammatory. And why should we increase inflammation in arthritis? I'm not an expert, but this should be checked.--Miguelferig (talk) 19:14, 13 August 2012 (UTC)

Fixed Good catch. Elsewhere in the article, it states that substance P is inflammatory and capsaicin reduces substance P levels, therefore capsaicin must be anti-flammatory. I have corrected this mistake. Boghog (talk) 19:49, 13 August 2012 (UTC)

confusion re undecapeptide in first sentence[edit]

The first sentence states 'In the field of neuroscience, substance P (SP) is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator.' The colon after neuropeptide implies that the following definition relates to all neuropeptides. Are all neuropeptides undecapeptides? And what is an undecapeptide? Such an obscure word surely needs a link or definition.

Depending on which is correct, the first sentence should either read something like:

In the field of neuroscience, substance P (SP) is a neuropeptide - an undecapeptide (a peptide composed of a chain of 11 amino acid residues) that functions as a neurotransmitter and neuromodulator.


In the field of neuroscience, substance P (SP) is a neuropeptide - a peptide that functions as a neurotransmitter and neuromodulator. Specifically, substance P is an undecapeptide - a peptide composed of a chain of 11 amino acid residues.

Jpedant (talk) 10:54, 1 October 2012 (UTC)

PMID 24705689 - Involvement of substance P and the NK-1 receptor in human pathology.[edit]

Muñoz M1, Coveñas R.

Amino Acids. 2014 Jul;46(7):1727-50.

doi: 10.1007/s00726-014-1736-9.

Epub 2014 Apr 6.

PMID 24705689

Involvement of substance P and the NK-1 receptor in human pathology.

Abstract [excerpt]

The peptide substance P (SP) .... . After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration. SP has been also implicated in pain, inflammation, hepatitis, hepatotoxicity, cholestasis, pruritus, myocarditis, bronchiolitis, abortus, bacteria and viral infection (e.g., HIV infection) and it plays an important role in cancer (e.g., tumor cell proliferation, antiapoptotic effects in tumor cells, angiogenesis, migration of tumor cells for invasion, infiltration and metastasis). ...

PMID 24705689

   [PubMed - in process]

Jumbled text in section "Inflammation"[edit]

The first part of section "Inflammation" is a mess, it looks like a cut & paste job gone wrong. It's also unclear how it relates to inflammation: SP initiates expression of almost all known immunological chemical messengers (cytokines).[19][20][21] Also, most of the cytokines, in turn, induce SP and the NK1 receptor.[22][23] SP is particularly excitatory to cell growth and multiplication.[24] via usual,[25] as well as oncogenic driver.[26] SP is a trigger for nausea and emesis,[27] -- (talk) 00:12, 27 May 2016 (UTC)

What does the P stand for?[edit]

The article says it isn't "pain" or "psychiatric", so what is it? Equinox 19:04, 22 May 2017 (UTC)