Tiglyl-CoA
Appearance
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Names | |
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IUPAC name
S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-2-methylbut-2-enethioate
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Identifiers | |
3D model (JSmol)
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MeSH | tiglyl-coenzyme+A |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C26H42N7O17P3S | |
Molar mass | 849.63 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Tiglyl-CoA is an intermediate in the metabolism of isoleucine.[1][2] It is an inhibitor of N-acetylglutamate synthetase.[3]
References
- ^ ROBINSON WG; BACHHAWAT BK; COON MJ (1956). "TIGLYL COENZYME A AND a-METHYLACETOACETYL COENZYME A, INTERMEDIATES IN THE ENZYMATIC DEGRADATION OF ISOLEUCINE". Journal of Biological Chemistry. 218 (1): 391–400. PMID 13278346.
- ^ "Showing metabocard for Tiglyl-CoA (HMDB02054)". The Metabolomics Innovation Centre (TMIC).
- ^ Coude, F X; Sweetman, L; Nyhan, W L (1979). "Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia". Journal of Clinical Investigation. 64 (6): 1544–1551. doi:10.1172/JCI109614. PMC 371306. PMID 500823.