UCHL3

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UCHL3
Protein UCHL3 PDB 1uch.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UCHL3, UCH-L3, ubiquitin C-terminal hydrolase L3
External IDs MGI: 1355274 HomoloGene: 4377 GeneCards: UCHL3
RNA expression pattern
PBB GE UCHL3 204616 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270952
NM_006002

NM_016723

RefSeq (protein)

NP_001257881
NP_005993

NP_057932.2
NP_057932

Location (UCSC) Chr 13: 75.55 – 75.61 Mb Chr 14: 101.65 – 101.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[3][4]

Interactions[edit]

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[5][6]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. doi:10.1126/science.2530630. PMID 2530630. 
  4. ^ "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)". 
  5. ^ Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696. 
  6. ^ Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970. 

Further reading[edit]