Ubiquitin C

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Ubiquitin C
Protein UBC PDB 1aar.png
PDB rendering based on 1aar.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBC ; HMG20
External IDs OMIM191340 MGI98889 HomoloGene128418 GeneCards: UBC Gene
RNA expression pattern
PBB GE UBC 208980 s at tn.png
PBB GE UBC 211296 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7316 22190
Ensembl ENSG00000150991 ENSMUSG00000008348
UniProt P0CG48 P0CG50
RefSeq (mRNA) NM_021009 NM_019639
RefSeq (protein) NP_066289 NP_062613
Location (UCSC) Chr 12:
125.4 – 125.4 Mb
Chr 5:
125.39 – 125.39 Mb
PubMed search [1] [2]

Polyubiquitin-C is a protein encoded by the UBC gene in humans.[1][2][3] It is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A.[4]


Ubiquitin C has been shown to interact with:


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  3. ^ "Entrez Gene: UBC ubiquitin C". 
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  23. ^ KIAA0753 Gene - GeneCards | K0753 Protein | K0753 Antibody, (available at http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIAA0753).
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  30. ^ Wagner, S. A.; Beli, P; Weinert, B. T.; Nielsen, M. L.; Cox, J; Mann, M; Choudhary, C (2011). "A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles". Molecular & Cellular Proteomics 10 (10): M111.013284. doi:10.1074/mcp.M111.013284. PMC 3205876. PMID 21890473.  edit
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  32. ^ Patel R, Maru G. "Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs". Free Radic. Biol. Med. 44 (11): 1897–911. doi:10.1016/j.freeradbiomed.2008.02.006. PMID 18358244. 
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  35. ^ Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K et al. "Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2". Proc. Natl. Acad. Sci. U.S.A. 105 (12): 4838–43. doi:10.1073/pnas.0712216105. PMC 2290789. PMID 18359851. 
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Further reading[edit]

  1. ^ KIAA0753 Gene - GeneCards | K0753 Protein | K0753 Antibody, (available at http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIAA0753).