The 2008 United States House of Representatives election in South Dakota took place on Tuesday, November 4, 2008. Voters selected a representative for their single At-Large district, who ran on a statewide ballot.
Democratic incumbent Stephanie Herseth Sandlin was challenged by the Republican nominee, businessman and attorney Chris Lien. Neither candidate was opposed in the June 3, 2008 primary. CQ Politics forecasted this race as 'Safe Democrat'.George W. Bush won in this district 61% to 39% for John Kerry in 2004. As of 2017, this is the last time that a Democrat won South Dakota's House seat.