User:Jennifer Rfm/5S ribosomal RNA

5S ribosomal RNA
5S ribosomal RNA
	Predicted secondary structure and sequence conservation of 5S ribosomal RNA
Identifiers
Symbol	5S_rRNA
Rfam	RF00001
Other data
RNA type	Gene; rRNA;
Domain(s)	Eukaryota;Bacteria;Viruses;Archaea;
GO	GO:0005840 GO:0003735
SO	SO:0000652
PDB structures	PDBe

5S ribosomal RNA (5S rRNA) is a component of the large ribosomal subunit in both prokaryotes (50S) and eukaryotes (60S).

Eukaryotic 5S rRNA is synthesised by RNA polymerase III, whereas most other eukaroytic rRNAs are cleaved from a 45S precursor transcribed by RNA polymerase I. In Xenopus oocytes, it has been shown that fingers 4-7 of the nine-zinc finger transcription factor TFIIIA can bind to the central region of 5S RNA.^[3] Binding between 5S rRNA and TFIIIA serves to both repress further transcription of the 5S RNA gene and stabilize the 5S RNA transcript until it is required for ribosome assembly.^[4]

References[edit]

^ Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R (2000). "The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution". J Mol Biol. 298 (1): 35–59. doi:10.1006/jmbi.2000.3635. PMID 10756104.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Mitra K, Schaffitzel C, Fabiola F, Chapman MS, Ban N, Frank J (2006). "Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements". Mol Cell. 22 (4): 533–43. doi:10.1016/j.molcel.2006.05.003. PMID 16713583.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Searles, M. A.; Lu, D.; Klug, A. (2000). "The role of the central zinc fingers of transcription factor IIIA in binding to 5 S RNA". J Mol Biol. 301 (1): 47–60. doi:10.1006/jmbi.2000.3946. PMID 10926492.{{cite journal}}: CS1 maint: date and year (link)
^ Pelham, H. R.; Brown, D. D. (1980). "A specific transcription factor that can bind either the 5S RNA gene or 5S RNA". Proc Natl Acad Sci. 77 (7): 4170–4174. doi:10.1073/pnas.77.7.4170. PMC 349792. PMID 7001457.{{cite journal}}: CS1 maint: date and year (link)

External links[edit]

Page for 5S ribosomal RNA at Rfam
5SData
5S+Ribosomal+RNA at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Category:Ribosomal RNA

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[pmid10756104-1] Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R (2000). "The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution". J Mol Biol. 298 (1): 35–59. doi:10.1006/jmbi.2000.3635. PMID 10756104.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid16713583-2] Mitra K, Schaffitzel C, Fabiola F, Chapman MS, Ban N, Frank J (2006). "Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements". Mol Cell. 22 (4): 533–43. doi:10.1016/j.molcel.2006.05.003. PMID 16713583.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[Searles_2000-3] Searles, M. A.; Lu, D.; Klug, A. (2000). "The role of the central zinc fingers of transcription factor IIIA in binding to 5 S RNA". J Mol Biol. 301 (1): 47–60. doi:10.1006/jmbi.2000.3946. PMID 10926492.{{cite journal}}: CS1 maint: date and year (link)

[Pelham_1980-4] Pelham, H. R.; Brown, D. D. (1980). "A specific transcription factor that can bind either the 5S RNA gene or 5S RNA". Proc Natl Acad Sci. 77 (7): 4170–4174. doi:10.1073/pnas.77.7.4170. PMC 349792. PMID 7001457.{{cite journal}}: CS1 maint: date and year (link)

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