User:Laffygramma

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David
Personal details
Born
wackbuilder

(2022-09-16) September 16, 2022 (age 19 months)
Brazil
Political partyWikipedia Party
EducationTeahouse University
Babel user information
pt-N Este utilizador tem como língua materna o português.
en-5 This user has professional knowledge of English.
Users by language
This user is a
Registered Editor
and is entitled to display this Service Badge.

Hello there! I am Lafo, Welcome to my Wikipedia page.

I'm a fellow user who reads pages most of the times, but sometimes I edit.

If you have anything to say, go to my talk page.


Thanks for reading!

Random Crap[edit]

Laura Moser
Personal details
Born (1977-08-30) August 30, 1977 (age 46)
Houston, Texas, U.S.
Political partyDemocratic
EducationAmherst College (BA)

Laura Moser (born August 30, 1977)[1] is an American author and politician who founded the anti-Trump resistance movement Daily Action. She was a candidate for the United States Congress in Texas's 7th congressional district.[2]


2010 World Junior Wrestling Championships
Host cityHungary Budapest, Hungary
Dates19–25 July 2010
Champions
Freestyle Russia
Greco-Roman Russia
Women Russia

The 2010 World Junior Wrestling Championships were the 33rd edition of the World Junior Wrestling Championships and were held in Budapest, Hungary between 19 and 25 July 2010.[3][4][5][6][7][8][9][10]

Laffygramma
Clinical data
Trade namesBelsomra
Other namesMK-4305; MK4305
AHFS/Drugs.comMonograph
MedlinePlusa614046
License data
Pregnancy
category
Dependence
liability		Low
Addiction
liability		Low
Routes of
administration		By mouth[12]
Drug classOrexin receptor antagonist; Hypnotic; Sedative
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability82% (10 mg; lower at higher doses)[12][16]
Protein binding99.5%[17][12]
MetabolismLiver (CYP3A major, CYP2C19 minor)[12]
MetabolitesHydroxysuvorexant (inactive)[12]
Elimination half-life12.2 hours (8–19 hours) (40 mg)[12][16][18]
ExcretionFeces: 66%[12]
Urine: 23%[12]
Identifiers
  • [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC23H23ClN6O2
Molar mass450.93 g·mol−1
3D model (JSmol)
  • C[C@@H]1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
  • InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1 checkY
  • Key:JYTNQNCOQXFQPK-MRXNPFEDSA-N checkY
  (verify)

Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia.[12][17] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset and/or maintenance in adults.[12][17] Suvorexant helps with falling asleep faster, sleeping longer, being awake less in the middle of the night, and having better quality of sleep.[12][19] Its effectiveness is modest,[20] and is similar to that of other orexin antagonists, but is lower than that of benzodiazepines and Z-drugs.[21] Suvorexant is taken by mouth.[12][22][17]

Side effects of suvorexant include somnolence, daytime sleepiness and sedation, headache, dizziness, abnormal dreams, dry mouth, and impaired next-day driving ability.[12][19][23] Rarely, sleep paralysis, sleep-related hallucinations, complex sleep behaviors like sleepwalking, and suicidal ideation may occur.[12][17][20] Tolerance, dependence, withdrawal, and rebound effects do not appear to occur significantly with the medication.[12][24][25] Suvorexant is a dual orexin receptor antagonist (DORA).[17] It acts as a selective dual antagonist of the orexin OX1 and OX2 receptors.[17] The medication has an intermediate elimination half-life of 12 hours and a time to peak of about 2 to 3 hours.[12][17] Unlike benzodiazepines and Z-drugs, suvorexant does not interact with GABA receptors, instead having a distinct mechanism of action.[17][26]

Clinical development of suvorexant began in 2006[27] and it was introduced for medical use in 2014.[12][28] The medication is a schedule IV controlled substance in the United States and may have a modest potential for misuse.[29][12][30] In other places, such as Australia, suvorexant is a prescription-only medicine and is not a controlled drug.[11] Suvorexant is not available in generic formulations.[22][31][32] Besides suvorexant, other orexin receptor antagonists like lemborexant and daridorexant have also been introduced.[33][34]

Billy Preston & Syreeta
Studio album by
Billy Preston, Syreeta Wright
Released1981
StudioMotown/Hitsville U.S.A. Recording Studios (Los Angeles, California)
  • Amerycan Studios (North Hollywood, California),
  • Kendun Recorders (Burbank, California)
GenreR&B, Soul
LabelMotown
Producer

Billy Preston & Syreeta is a 1981 album of duets by Billy Preston and Syreeta released by Motown Records.[35] Six songs were produced by Ollie Brown, and four songs were produced and co-written by Michael Masser. An expanded version of the album with 10 songs and 7 bonus cuts was released on CD in late 2013 on SoulMusic Records.[36]

Shire of Gayndah
Queensland
Location within Queensland
Population2,911 (2006 census)[37]
 • Density1.07445/km2 (2.7828/sq mi)
Established1866
Area2,709.3 km2 (1,046.1 sq mi)
Council seatGayndah
RegionWide Bay–Burnett
WebsiteShire of Gayndah
LGAs around Shire of Gayndah:
Eisdvold Perry Biggenden
Mundubbera Shire of Gayndah Biggenden
Wondai Kilkivan Biggenden

The Shire of Gayndah was a local government area located in the northern catchment of the Burnett River, Queensland, Australia. The shire covered an area of 2,709.3 square kilometres (1,046.1 sq mi), and existed as a local government area from 1866 until 2008, when it amalgamated with several other shires to form the North Burnett Region.

Major activities in the shire included citrus production, beef and timber.

Wackbuilder[edit]

Joseph Elias Wack
Personal details
Born
José Elias Vaque da Silva

(2001-05-14)May 14, 2001
Rio de Janeiro, Rio de Janeiro (state), Brazil
DiedNovember 28, 2022(2022-11-28) (aged 21)
London, UK
EducationWikimedia University

Joseph Elias Wack (May 14, 2001 - November 28, 2022) was a Brazilian author known for his online stories. Wack was shot dead while in London by "Spacebuilder" because he had exposed Spacebuilder as a pedophile.

  1. ^ "Jewish Women's Archive. "Laura Moser"". Retrieved 17 June 2017.
  2. ^ Diaz, Kevin (3 May 2017). "In the age of Trump, Democrats zero in on a longtime GOP House seat". Houston Chronicle. Retrieved 26 June 2017.
  3. ^ "International Wrestling Database".
  4. ^ "International Wrestling Database".
  5. ^ "International Wrestling Database".
  6. ^ "International Wrestling Database".
  7. ^ "International Wrestling Database".
  8. ^ "International Wrestling Database".
  9. ^ "Azerbaijan Greco-Roman Wrestling Team Ranks Second in World Championship".
  10. ^ "2010 Junior World Wrestling Championships".
  11. ^ a b Cite error: The named reference Belsomra-AU-Label was invoked but never defined (see the help page).
  12. ^ a b c d e f g h i j k l m n o p q r s t "Belsomra- suvorexant tablet, film coated". DailyMed. Retrieved 30 January 2020.
  13. ^ Cite error: The named reference Drugs.com-Pregnancy was invoked but never defined (see the help page).
  14. ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  15. ^ "Search Page - Drug and Health Product Register". 23 October 2014.
  16. ^ a b Cite error: The named reference MerckSharpDohme2013 was invoked but never defined (see the help page).
  17. ^ a b c d e f g h i Jacobson LH, Callander GE, Hoyer D (November 2014). "Suvorexant for the treatment of insomnia". Expert Review of Clinical Pharmacology. 7 (6): 711–730. doi:10.1586/17512433.2014.966813. PMID 25318834. S2CID 41099462.
  18. ^ Cite error: The named reference DimovaBrarMen2014 was invoked but never defined (see the help page).
  19. ^ a b Cite error: The named reference pmid28365447 was invoked but never defined (see the help page).
  20. ^ a b Cite error: The named reference pmid26648692 was invoked but never defined (see the help page).
  21. ^ Cite error: The named reference pmid35843245 was invoked but never defined (see the help page).
  22. ^ a b Cite error: The named reference Drugs.com-Belsomra-Generic was invoked but never defined (see the help page).
  23. ^ Kishi T, Matsunaga S, Iwata N (2015). "Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials". PLOS ONE. 10 (8): e0136910. Bibcode:2015PLoSO..1036910K. doi:10.1371/journal.pone.0136910. PMC 4552781. PMID 26317363.
  24. ^ Cite error: The named reference pmid28994603 was invoked but never defined (see the help page).
  25. ^ Cite error: The named reference pmid32901578 was invoked but never defined (see the help page).
  26. ^ Atkin T, Comai S, Gobbi G (April 2018). "Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery". Pharmacological Reviews. 70 (2): 197–245. doi:10.1124/pr.117.014381. PMID 29487083. S2CID 3578916.
  27. ^ Cite error: The named reference pmid25406050 was invoked but never defined (see the help page).
  28. ^ Cite error: The named reference APDNews2014 was invoked but never defined (see the help page).
  29. ^ Cite error: The named reference FederalRegister2016 was invoked but never defined (see the help page).
  30. ^ Cite error: The named reference pmid25231363 was invoked but never defined (see the help page).
  31. ^ Cite error: The named reference pmid30092886 was invoked but never defined (see the help page).
  32. ^ Cite error: The named reference pmid26955275 was invoked but never defined (see the help page).
  33. ^ Cite error: The named reference pmid35043499 was invoked but never defined (see the help page).
  34. ^ Cite error: The named reference pmid35298826 was invoked but never defined (see the help page).
  35. ^ discogs: Billy Preston & Syreeta – Billy Preston & Syreeta, LP 1981
  36. ^ discogs: Billy Preston & Syreeta – Billy Preston & Syreeta (Expanded CD Edition)
  37. ^ Australian Bureau of Statistics (25 October 2007). "Gayndah (S) (Local Government Area)". 2006 Census QuickStats. Retrieved 18 March 2008.
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