VAV2

VAV2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Identifiers
Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDs	OMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,992,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,317,045 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; ganglionic eminence; ; ventricular zone; ; body of pancreas; ; right lobe of liver; ; caput epididymis; ; right adrenal cortex; ; corpus epididymis; ; left adrenal cortex; ; jejunal mucosa;
	Top expressed in
	habenula; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; medullary collecting duct; ; seminal vesicula; ; cumulus cell; ; seminiferous tubule; ; conjunctival fornix; ; ganglionic eminence; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding; metal ion binding; protein binding; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; plasma membrane;
Biological process	regulation of cell size; intracellular signal transduction; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of GTPase activity; ephrin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; platelet activation; Fc-epsilon receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; cell projection assembly; angiogenesis; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; cell migration; signal transduction; lamellipodium assembly; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7410
	22325
	ENSG00000160293
	ENSMUSG00000009621
	P52735
	Q60992
	NM_001134398; NM_003371
	NM_009500
	NP_001127870; NP_003362
	NP_033526
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.^[5]^[6]

Template:PBB Summary

Interactions

VAV2 has been shown to interact with CD19^[7] and Grb2.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160293 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009621 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet. 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982.
^ "Entrez Gene: VAV2 vav 2 oncogene".
^ Doody, G M; Billadeau D D; Clayton E; Hutchings A; Berland R; McAdam S; Leibson P J; Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22). ENGLAND: 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3). United States: 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Bourguignon, L Y; Zhu H; Zhou B; Diedrich F; Singleton P A; Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52). United States: 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading